Results 41 to 50 of about 1,205 (134)

Mechanochemically Driven Synthesis of Anticancer Cocrystals: A Case Study of Lenalidomide

Chemistry–Methods, Volume 6, Issue 5, May 2026.
The combination of crystal engineering and mechanochemical approaches is a powerful strategy for the rational screen and development of new solid forms of active pharmaceutical ingredients (API). New supramolecular patterns formed between an API and a coformer allow the adjustment of physicochemical properties of drugs.
Ana C. S. Carvalho, M. Teresa Duarte, Clara S. B. Gomes, Mafalda Sarraguça, Alessia Bacchi, Michele Prencipe, Job Gieling, Natalia Shemchuk, Daniel M. Baier, Koen Robeyns, Hector Polyzois, Lidia Tajber, Christos M. Chatzigiannis, Evelina Colacino, Tom Leyssens, Vânia André   +15 more
wiley   +1 more source

Desulfurization of Benzothiophene Derivatives by Solvent Extraction Coupled With Oxidation Using Oxomolybdenum(VI) Bis(pyrazolyl)methane Catalysts

European Journal of Inorganic Chemistry, Volume 29, Issue 13, 1 May 2026.
A polymeric hybrid material formulated as [MoO3(bis(pyrazolyl)methane)] has been prepared and used as a catalyst precursor for the complete oxidative desulfurization of a model diesel containing recalcitrant benzothiophene derivatives. The precursor is converted in situ to an oxodiperoxo active species which is retained in the recyclable extractant ...
Ana C. Gomes, Fátima Mirante, Isabel S. Gonçalves, Martyn Pillinger, Salete S. Balula   +4 more
wiley   +1 more source

Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT The enteric nervous system (ENS), a key component of the gut–brain axis, has emerged as a critical player in the pathogenesis of Parkinson's disease (PD). It is the first neural system exposed to food contaminants (FCs)—a diverse group of ubiquitous toxic compounds fortuitously present in food derived from production, processing, storage, or ...
Helena Ramos, Ana Margarida Araújo, Isabel M. P. L. V. O. Ferreira, Miguel A. Faria   +3 more
wiley   +1 more source

Drug Delivery Systems on Leprosy Therapy: Moving Towards Eradication?

Pharmaceutics, 2020
Leprosy disease remains an important public health issue as it is still endemic in several countries. Mycobacterium leprae, the causative agent of leprosy, presents tropism for cells of the reticuloendothelial and peripheral nervous system.
Luíse L. Chaves, Yuri Patriota, José L. Soares-Sobrinho, Alexandre C. C. Vieira, Sofia A. Costa Lima, Salette Reis   +5 more
doaj   +1 more source

Design, Synthesis, and Evaluation of New Polyhydroxylated Bis‐Chalcones as Potential COX‐2 Selective Inhibitors

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Novel polyhydroxylated bis‐chalcones were successfully synthesized and demonstrated COX‐2 selective inhibition. The most potent and selective inhibitor exhibited a mixed‐type inhibition mechanism with COX‐2. Its additional bulk preferentially blocked the access to the active pocket of COX‐1 rather than COX‐2. Selective inhibition of COX‐2 is considered
Rui Pereira, Alberto N. Araújo, Daniela Ribeiro, Ismael Rufino, Nuno Martinho, Rita C. Guedes, Vera L. M. Silva, Eduarda Fernandes   +7 more
wiley   +1 more source

Rendimiento de tres cultivares de arveja (Pisum sativum L.) con aplicación de fertilizantes químicos y orgánicos en el anexo de Taquia, Chachapoyas

Revista de Investigación en Agroproducción Sustentable, 2017
La presente investigación se realizó en el anexo de Taquia y tuvo como objetivo evaluar el rendimiento de tres cultivares de arveja con aplicación de fertilización química y orgánica, para ello se utilizó un diseño en Bloques Completamente al Azar (DBCA)
Roicer Collazos Silva, Juan Carlos Neri Chávez, Eyner Huamán Huamán   +2 more
doaj   +1 more source

Fluoroquinolone Metalloantibiotics to Bypass Antimicrobial Resistance Mechanisms: Decreased Permeation through Porins

Membranes, 2020
Fluoroquinolones (FQs) are broad-spectrum antibiotics largely used in the clinical practice against Gram-negative and some Gram-positive bacteria. Nevertheless, bacteria have developed several antimicrobial resistance mechanisms against such class of ...
Mariana Ferreira, Carla F. Sousa, Paula Gameiro   +2 more
doaj   +1 more source

Eco‐Microbiology: A Frugal‐Circular Framework for Biosafe, Low‐Cost Practical Microbiology in Secondary Education

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
Eco‐Microbiology: a frugal‐circular pedagogical framework for biosafe, low‐cost, low‐impact microbiology in secondary education—This graphical abstract summarises the Eco‐Microbiology framework, which integrates frugality as a behavioural and design principle (minimal extraction, maximal conservation and upstream waste prevention) alongside biosafety ...
Lara Amorim, Kenneth Timmis, Betina da Silva Lopes, Raquel Ribeiro, Conceição Santos   +4 more
wiley   +1 more source

Análisis del balance energético de diferentes sistemas de manejo agroecológico del suelo, en el cultivo del maíz (Zea mays L.)

Revista de Investigación Agraria y Ambiental, 2012
En un suelo Typic Haplustalfs (USDA) del municipio de Palmira, Valle del Cauca (Colombia), se estableció el sistema de rotación fríjol terciopelo Mucuna pruriens Var. Utilis-maíz Zea mays L., en diseño de bloques completos al azar, con siete tratamientos
Óscar Eduardo Sanclemente Reyes, Carlos Omar Patiño Torres, Liliana Rocío Beltrán Acevedo   +2 more
doaj   +1 more source

Peri‐Implant Crevicular Fluid Analysis by Mid‐Infrared Spectroscopy in Peri‐Implantitis—A Pilot Study

Clinical Oral Implants Research, Volume 37, Issue 4, Page 453-467, April 2026.
ABSTRACT Objectives This study aimed to assess biochemical differences in peri‐implant crevicular fluid (PICF) using ATR‐FTIR spectroscopy and multivariate analysis, through a between‐participant comparison of healthy and peri‐implantitis (PI) sites, and a within‐participant comparison of PI‐PICF and GCF from contralateral periodontal healthy teeth ...
Francisco Maligno, Ricardo N. M. J. Páscoa, Pedro S. Gomes   +2 more
wiley   +1 more source