Results 131 to 140 of about 69,680 (260)

Intramolecular Interactions between Folded and Disordered Regions Shape Ubiquilin Structure and Function

open access: yesAdvanced Science, EarlyView.
Ubiquilin (UBQLN), like many other human proteins, contains both well‐folded and disordered regions. Here, we show that intramolecular interactions between disordered regions and folded domains modulate between open and closed topologies of UBQLN proteins, altering their structure and function.
Jessica K. Niblo   +4 more
wiley   +1 more source

Ultrafast Hot‐Carrier Cooling in CsPbBr3 Supercrystals via Long‐Range Electronic Coupling

open access: yesAdvanced Science, EarlyView.
CsPbBr3 supercrystal self‐assembly, which induces long‐range electronic coupling, enables spatial carrier delocalization that accelerates carrier‐LO phonon scattering and weakens the Auger heating. These effects enable ultrafast, excitation‐intensity‐independent hot‐carrier cooling, offering a trade‐off‐free strategy for high‐performance perovskite ...
Junhong Yu   +9 more
wiley   +1 more source

Accurately Deciphering Tissue Heterogeneity From Spatial Multi‐Modal and Multi‐Omics With STransformer

open access: yesAdvanced Science, EarlyView.
STransformer is a unified deep learning framework designed to seamlessly accommodate a comprehensive landscape of spatial data. By simultaneously capturing short‐range cellular interactions and tissue‐wide semantic patterns, it extracts robust representations to accurately dissect complex tissue heterogeneity.
Xingyi Li   +9 more
wiley   +1 more source

Machine Learning‐Enhanced Ultrasensitive Immuno‐CRISPR Array Facilitates Early Diagnosis of Alzheimer's Disease by Detecting Multiple Plasma Biomarkers

open access: yesAdvanced Science, EarlyView.
This work presents a CRISPR‐based, ultrasensitive multiplex protein detection array capable of simultaneously analyzing six plasma biomarkers associated with Alzheimer's disease (AD). By integrating antibody‐mediated signal transduction, recombinase polymerase amplification, and spatially encoded CRISPR‐Cas12a, the system achieves detection sensitivity
Liding Zhang   +9 more
wiley   +1 more source

Bio-Inspired 3D-Printed Polymeric Sheets for Orthoses: Predictive Modeling of Mechanical Integrity and Moisture Absorption. [PDF]

open access: yesBiomimetics (Basel)
Devesa-Rey R   +4 more
europepmc   +1 more source

Laser Preset of MnOx Layer on High‐Entropy Alloy Surface for Ampere‐Level Ultra‐Stable OER Performance

open access: yesAdvanced Science, EarlyView.
3D printing enables a high entropy alloy‐derived, in situ formed MnOx overlayer that suppresses oxidation–reconstruction and mitigates anodic dissolution, while enhancing electrolyte wetting and bubble release to accelerate interfacial mass transport and OER kinetics.
Benzhi Wang   +8 more
wiley   +1 more source

Traits Explain Canopy Tree Occurrence Along Regional Environmental Gradients: A Subset Combine to Be Useful. [PDF]

open access: yesEcol Evol
Vesk PA   +6 more
europepmc   +1 more source

ORBIT‐AMD: Ordinal Risk, Bilateral Imaging, and Trajectory Learning for Age‐Related Macular Degeneration in Multi‐Cohorts

open access: yesAdvanced Science, EarlyView.
Eligibility flow and real‐world AMD burden in the UKB retinal imaging cohort and TMUEH external‐validation cohort. Overview of the ORBIT‐AMD architecture, integrating retinal representation pretraining, bilateral eye‐graph modeling and concept bottleneck learning to support ordered risk, bilateral context, interpretable lesion concepts, longitudinal ...
Xuehao Cui   +3 more
wiley   +1 more source

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