Results 81 to 90 of about 104,914 (298)

A FAP‐Targeted SMDC Platform Enables Synergistic Radionuclide–Chemotherapy with PET‐Guided Evaluation

Advanced Science, EarlyView.
A fibroblast activation protein (FAP)‐targeted small molecule–drug conjugate (SMDC) platform is developed to integrate PET imaging with synergistic radionuclide–chemotherapy. Linker chemistry governs stability, exposure, and tolerability, with the VC linker providing superior in vivo performance.
Ruitao Yang, Hongxin Li, Zexin Xu, Baocheng Chen, Ningjie Li, Yuhua Zhong, Kongzhen Hu   +6 more
wiley   +1 more source

Scalable High‐Force Zipping Electrostatic Actuators

Advanced Intelligent Systems, EarlyView.
An electrostatic actuator architecture is presented that combines high energy density with forces and strokes suited for wearable soft robotics. By folding patterned thin films into a scalable honeycomb of zipping units, performance becomes tunable through series–parallel design, achieving over 40 N and 28 J/kg.
Fabio Caruso, Amir Firouzeh, Herbert Shea   +2 more
wiley   +1 more source

m.10010T>C Mitochondrial Disease: A Case Report With Hypoparathyroidism and Review of the Literature

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Mitochondria are essential intracellular organelles that play a critical role in cellular metabolism, including the regulation of intracellular calcium signaling. Advances in genomic sequencing have facilitated the identification of rare pathogenic mitochondrial DNA (mtDNA) genetic variants in patients with unexplained endocrine disorders.
Jacob Mohr, Anja Lisbeth Frederiksen, Morten Duno, Anne Pernille Hermann, Trine Maxel Juul, Simone Rask Nielsen   +5 more
wiley   +1 more source

Evaluation of quantitative muscle MRI and an intelligent phenotyping housing system as advanced phenotyping methods in a mouse model of calpain 3‐deficient muscular dystrophy

Animal Models and Experimental Medicine, EarlyView.
We applied quantitative MRI of the lower limb and automated home‐cage phenotyping to a mouse model of calpainopathy to detect early disease changes. At 15 months, calpain 3‐deficient mice showed increased water T2 values correlating with immune cell infiltration in the soleus and gastrocnemius muscles, while assessment of motor activity revealed only ...
Nicolina Südkamp, Marlena Rohm, Gabriele Russo, Xavier Helluy, Abdulhadi Kocabas, Martijn Froeling, Felix Kleefeld, Denise Manahan‐Vaughan, Tobias Ruck, Frank Jacobsen, Matthias Vorgerd, Johannes Forsting, Lara Schlaffke   +12 more
wiley   +1 more source

Born this way: Does variation in perinatal limb bone morphology predict adult locomotor repertoire in primates?

The Anatomical Record, EarlyView.
Abstract Primates show a high degree of locomotor diversity that engenders similar variance in limb bone cross‐sectional geometry and bending strength: leaping primates have stronger hindlimb bones whereas suspensory species have stronger forelimb bones.
Angela M. Mossor, Jeremy Busken, Lorna Benden, Ethan Mardovin, Andrew Bostick, Grégoire Boulinguez‐Ambroise, Timothy D. Smith, Jesse W. Young   +7 more
wiley   +1 more source

PRELIMINARY CROSS-SECTIONAL RELIABILITY OF MYO-TECH IN MEASURING QUADRICEPS CONTRACTION AMONG ACL PATIENTS

International Journal of Physiotherapy, 2020
Background: The Anterior Cruciate Ligament (ACL) injury is the most traumatic knee joint injury. Surgical reconstruction is the common standard treatment care to ensure an early functional gain.
Nabilah Ahmad, Izham Zain, Azri Hisham Azizon, Nur Asyikin Zol, Verena Edward Cheong Abdullah, Khairul Fizi Md. Kasir, Saadatul Suhaili Abdul Latif   +6 more
doaj   +1 more source

Quadriceps Injuries in Major League Soccer: A 10‐Year Analysis of Injury Rate, Return‐to‐Play, and Performance Metrics

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To evaluate quadriceps injury rates, return‐to‐play (RTP) durations, and postinjury performance in Major League Soccer (MLS) athletes with quadriceps injuries. Methods Data from MLS players with quadriceps injuries (2010‐2021) were analyzed using the MLS Injury Surveillance database.
Brian Forsythe, Catherine Hand, Camden Bohn, Daanish Khazi‐Syed, Joshua Chang, Francis Hand, Harmanjeet Singh, Andrew Savoia, Jonathan Spaan, Eric Giza, Margot Putukian, Bert R. Mandelbaum   +11 more
wiley   +1 more source

Effects of Sacroiliac Joint Mobilization on Hamstring Muscle Flexibility and Quadriceps Muscle Strength

Orthopaedic Journal of Sports Medicine, 2014
Objectives: The aim of this study was to determine the effect of sacroiliac joint mobilization (SJM) in cases with sacroiliac joint dysfunction (SJD) on hamstring muscle flexibility and quadriceps muscle strength. Methods: Seven subjects age average (min-
Seval Tamer, Müzeyyen Öz, Özlem Ülger   +2 more
doaj   +1 more source

Evaluation of the safety,effectiveness,and health-related QOL impact of early rehabilitation in patients with nephrotic syndrome [PDF]

, 2020
鈴鹿医療科学大
岩井 宏治
core   +1 more source

Significant Deficits Are Seen in Extensor Muscle Performance but Not Flexor Muscle Performance 6 Months After Anterior Cruciate Ligament Reconstruction Using a Rectus Femoris Tendon Autograft

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To evaluate bilateral isokinetic performance symmetry of knee extensors and flexors 6 months after anterior cruciate ligament reconstruction using a rectus femoris tendon autograft. Methods This retrospective case series included patients consecutively recruited at a single tertiary sports medicine center between January 2023 and July 2024 ...
Alef Cavalcanti Matias de Barros, Márcio Cabral Fagundes Rêgo, Karinna Sonálya Aires da Costa Oliveira, Marcelo Cabral Fagundes Rêgo, Carlos Eduardo da Silveira Franciozi, Diego Ariel de Lima, Camilo Partezani Helito, José Leonardo Rocha de Faria, Jamilson Simões Brasileiro   +8 more
wiley   +1 more source