Knotted folds induced by homochiral all-parallel (or all-antiparallel) double-helices. [PDF]
PNAS NexusHyde ST, Evans ME, Metzke CAR, Taylor N.
europepmc +1 more source
Characterization of the Interaction of Known G‐quadruplex Ligands With a Minimal i‐Motif Structure
Chemistry – A European Journal, Volume 32, Issue 37, 1 October 2026.The destabilization of a minimal i‐Motif (iM) structure by TMPyP4 is driven by ligand recognition of one terminal iM structural domain. ABSTRACT Peculiar genomic regions are prone to evolve transiently from double‐helix DNA to noncanonical secondary structures in response to physiological stress.
Davide Auricchio +3 more
wiley +1 more source
Structural insights into YheS-mediated release of SecM-arrested ribosome. [PDF]
Nat CommunIso K +9 more
europepmc +1 more source
Report on bioeconomy Quadruple Helix innovation ecosystems
The report identifies the needs and priorities of QH stakeholders so that bioeconomy research and education activities performed by HEIs can be aligned with them.
openaire +1 more source
MedComm, Volume 7, Issue 10, October 2026.The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley +1 more source
From evidence to practice: stakeholder-driven methods to culturally adapting prevention programs addressing substance use and mental health. [PDF]
Transl Behav MedCorpus-Espinosa C +2 more
europepmc +1 more source
Anti‐idiotypic antibodies as molecular mimics of conserved influenza hemagglutinin epitopes
Protein Science, Volume 35, Issue 10, October 2026.Abstract Broadly neutralizing antibodies (bNAbs) provide insights for developing universal influenza vaccines through their ability to neutralize diverse viral strains. However, designing antigens that reliably elicit bNAb responses remains challenging due to the difficulty in targeting conserved epitopes with a single antigen.
Hiroshi Itou +7 more
wiley +1 more source
A Single Amino Acid in the A2 Linker of Cholera Toxin Affects the Efficiency of Toxin Disassembly and Resulting Toxicity. [PDF]
ACS OmegaKersten F +10 more
europepmc +1 more source
Dualsteric and dual‐acting modulation of muscarinic receptors by antagonist KH‐5
British Journal of Pharmacology, Volume 183, Issue 19, Page 5769-5790, October 2026.Abstract Background and purpose Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH‐5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors.
Alena Janoušková‐Randáková +3 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 20, Page 6179-6198, October 2026.Background and Purpose Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder caused primarily by loss‐of‐function mutations in the voltage‐gated potassium channel Kv1.1 (KCNA1). Small molecules that restore Kv1.1 activity hold promise as targeted therapies for EA1, yet current pharmacological strategies remain limited ...
Rían W. Manville +6 more
wiley +1 more source