Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Erratum: The Qualification Examination for Specialists and Instructors in the Japanese Society of Neuroendovascular Therapy: History and Current Status. [PDF]
europepmc +1 more source
Construction of a comprehensive value assessment framework for renal denervation therapy: a decision-support tool for Chinese hospital management. [PDF]
Liu C, Lin M, Xu F, Yan Y, Tao L.
europepmc +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Virtualization as a New Scaling Law for Semiconductor Devices Beyond Geometric Scaling. [PDF]
Wang Z +8 more
europepmc +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Value of whole-process quality control management in central sterile supply department nursing practice and nosocomial infection prevention. [PDF]
Wang F, Zhao N.
europepmc +1 more source
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Safety and Learning Curve of Robotic Rectal Surgery Performed by Young Non-Endoscopic Surgical Skill Qualification System (ESSQS)-Qualified Surgeons: A Single-Center Retrospective Study. [PDF]
Saito H +6 more
europepmc +1 more source

