Results 161 to 170 of about 244,037 (301)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Restructuring Directions for the Korean Qualification System

, 2000
본 연구의 목적은 국민의 평생직업능력개발과 국가 인력개발정책을 주도 할 수 있는 자격제도를 구축하기 위하여 자격제도의 종합적인 개편 방안을 마련하는 것이다. 연구 목적을 달성하기 위한 구체적인 하위 연구목표는 다음과 같다. 1) 우리 나라 자격제도 개편의 필요성 탐색 2) 주요국의 자격제도 개혁 실태 및 시사점 분석 3) 자격제도 개편을 위한 국내의 여건 분석 4) 자격제도의 기본틀 개발The purpose of this study ...
신명훈
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Racial and ethnic disparities in GLP-1 prescriptions among veterans with obesity across direct and community care settings. [PDF]

Health Aff Sch
Stein RI, Phelan J, Frakt AB, Pizer SD, Garrido M, Orav EJ, Figueroa JF, Tsai TC.   +7 more
europepmc   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Artificial Intelligence for Regulatory Evidence: A Systematic Document Analysis of European Medicines Agency Regulatory Advice and Public Reports. [PDF]

Clin Pharmacol Ther
Nollen LM, van Westen GJP, Westman G, Pasmooij AMG.   +3 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Digital Transformation of Budget Funds Monitoring and Analysis of Their Effective Use. – Manuscript qualification work

Голубков В. С. Цифрова трансформація моніторингу бюджетних коштів та аналіз їх ефективного використання : кваліфікаційна робота магістра : спец. 122 Комп’ютерні науки; освітньо-професійна програма : Комп’ютерні науки; форма навчання : денна / Віктор ...
Holubkov, V., Голубков, Віктор Сергійович   +1 more
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Extracellular Vesicles as Enabling Biomarkers for New Approach Methodologies to Support the US Food and Drug Administration Modernization Act 3.0. [PDF]

J Extracell Vesicles
Rowland A, Kirkpatrick C, Rodrigues AD, Frevert U, Haderk F, Greening DW, McLachlan AJ, Hopkins A, Lucien F, Nieuwland R.   +9 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Development of a car sales site using REACT.JS. - Qualification work on manuscript rights

Агеєнко Р.О. Розробка сайту з продажу авто засобами REACT.JS : кваліфікаційна робота бакалавра : спец. 122 Комп’ютерні науки / Роман Олександрович Агеєнко // Факультет математики, природничих наук та технологій, кафедра інформатики, програмування ...
Агеєнко, Роман Олександрович, Ageyenko, R.   +1 more
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