FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
THE PROBATIONARY PERIOD FOR A FIXED-TERM EMPLOYMENT CONTRACT
Вестник университета, 2019 In the article the peculiarities of concluding a fixed term employment contract when hiring employees whose job is temporary, seasonal. Therefore, the analysis of the duration of the probationary period, noted some categories of people having the right ...
T. Suvalova
doaj
An integrated approach : holistic assessment of vocational trainees in the NZ dairy farming industry : a thesis presented in partial fulfilment of the requirements for the degree of Master of Education (Tertiary Education) at Massey University, Manawatu, New Zealand [PDF]
, 2016 Vocational training qualifications in New Zealand have undergone significant change since 2008 due to the Targeted Review of Qualifications (TRoQ) initiated by the New Zealand Qualifications Authority (NZQA).
Couper, Graeme William
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Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Information about occupations in the activityof the regional labour office [PDF]
Edukacja Ustawiczna Dorosłych, 2019 One of the tasks carried out by the Regional Labour Offices in Poland is the coordination and provision of career guidance and career information services as well as activities in the field of international job placement within the framework of the EURES
Anna Kicior
doaj
Managing the transition from Funding Qualifications on the National Qualifications Framework (NQF) to Funding Qualifications on the Qualifications and Credit Framework (QCF) [PDF]
, 2010 "Offers an update on the process for the transition from funding qualifications on the NQF to funding qualifications on the QCF for learners aged 19 and over in England.
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Craft vocational training on the example of selected descriptions about occupations [PDF]
Edukacja Ustawiczna Dorosłych, 2019 On the Polish ground there are currently 132 professions corresponding to a given type of craft in a dozen or so branches. They are characterized by pluriformity of hard, i.e.
Andrzej Wojciech Stępnikowski
doaj
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source