Results 121 to 130 of about 908,678 (344)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
More Qualifications and Less Dropout? From Compulsory Schooling to Vocational Education in Italy
, 2016 Erica Raimondi
openalex +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
New GCSEs in vocational subjects : an employers’ guide and overview of the new qualifications [PDF]
, 2002 "The purpose of this leaflet is to give employers an overview of the new General Certificate of Secondary Education (GCSE) in vocational subjects and to identify ways in which businesses can support the learning objectives of the qualifications which ...
core
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Taking regulatory action [PDF]
, 2011 "This document sets out the approach we intend to follow in exercising our statutory powers to take regulatory action. It is consistent with the Act in its description of our powers, the way in which we will exercise them, and the matters to which we ...
core
Qualifications, Skills, and Workforce Effectiveness: The Relevance of the OECD’s Survey of Adult Skills to Asia [PDF]
, 2012 William Thorn, Andreas Schleicher
openalex +1 more source