Results 61 to 70 of about 568,105 (304)

CORE: Cholesterol Altered Lipid Nanoparticles for Splenic Expression of mRNA Payloads

Advanced Healthcare Materials, EarlyView.
In this paper researchers introduce CORE LNPs, a new class of lipid nanoparticles engineered to redirect mRNA expression away from the liver and into the spleen, a key immune organ. By combining chemical design with computational tools, they created cholesterol analogs that enable precise spleen‐targeted expression, providing greater applications for ...
Eshan A. Narasipura, Vincent Fung, Rachel VanKeulen‐Miller, Palas B. Tiwade, Owen S. Fenton   +4 more
wiley   +1 more source

Bottom‐Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues

Advanced Materials, EarlyView.
A bottom‐up biomaterial platform is developed to program transcriptomic states in pancreatic cancer organoids by tuning adhesion cues within synthetic matrices. By combining a Design of Experiments framework with multiobjective optimization, matrix compositions are identified that enrich specific cellular programs like EMT.
Ali Nadernezhad, Verena J. Kast, Dagmar Pette, Franziska Baenke, Daniel E. Stange, Carsten Werner, Daniela Loessner   +6 more
wiley   +1 more source

Influence of weaning age (28 vs. 63 d) on quantitative and qualitative carcass traits of rabbits [PDF]

, 2005
Nowadays there is an increasing interest towards breeding systems, also for rabbit meat production, that are more mindful of animal welfare through an attenuation of the productive cycles intensity.
Bovera, Fulvia, Marongiu, Maria Laura, Moniello, Giuseppe, Nizza, Antonino, Pinna, Walter   +4 more
core   +1 more source

Considerations on the evolution of qualitative multistate traits [PDF]

Acta Biotheoretica, 1979
Simple models for the evolution of qualitative multistate traits are considered, in which the traits are permitted to evolve in time-dependent versus speciation-dependent fashion. Of particular interest are the means and variances of distances for these traits in evolutionary phylads characterized by different rates of speciation, when alternative ...
openaire   +3 more sources

Transducers Across Scales and Frequencies: A System‐Level Framework for Multiphysics Integration and Co‐Design

Advanced Materials Technologies, EarlyView.
Transducers convert physical signals into electrical and optical representations, yet each mechanism is bounded by intrinsic trade‐offs across bandwidth, sensitivity, speed, and energy. This review maps transduction mechanisms across physical scale and frequency, showing how heterogeneous integration and multiphysics co‐design transform isolated ...
Aolei Xu, Mengyao Xiao, Zhouli Sui, Yinpeng Wang, Daoye Zheng, Yuxin Liu, Luwei Wang, Huajun Liu, Chengkuo Lee   +8 more
wiley   +1 more source

Morphological and yield trait-based evaluation and selection of chili (Capsicum annuum L.) genotypes suitable for both summer and winter seasons

Open Agriculture
Chili (Capsicum annuum L.) is one of the most important vegetable cum spice crops grown throughout the world. Evaluation of genotypes based on morphological and yield contributing traits provides the opportunity to assess variability and select superior ...
Ratna Mahmuda, Chowdhury Abul Kashem, Mahmud Firoz, Rohman Md. Motiar, Ali Mohammad Zulficar, Syed Md. Abu, Almoallim Hesham S., Ansari Mohammad Javed, Hossain Akbar   +8 more
doaj   +1 more source

Telomere‐to‐Telomere Genomes Reveal that Multiscale Evolution Shapes the Largest Metabolic Arsenal of Diaporthe Fungi

Advanced Science, EarlyView.
This study presents the first telomere‐to‐telomere genomes and population resources for Diaporthe pathogens, uncovering the largest known fungal repertoire of secondary metabolite gene clusters. Structural variations and horizontal gene transfer drive cluster diversification, while specific rapidly evolving clusters control virulence, offering novel ...
Kainan Li, Chen Zhang, Zhichao Zhang, Jiaheng Cheng, Qiuyan Gao, Long Gao, Xiaolin Zhao, Wei Yan, Yuanchao Wang, Wenwu Ye   +9 more
wiley   +1 more source

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque [PDF]

, 2011
Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events.
A Dehghan, Aaron Isaacs, Abbas Dehghan, AD Johnson, AD Johnson, Afshin Parsa, Alan R Shuldiner, Albert Hofman, Albert V Smith, AM Bennet, Andre Uitterlinden, Andreas Ziegler, Angelo Scuteri, Anne B Newman, Arne Schillert, Ben Oostra, BM Psaty, Bolli Thorsson, Braxton D Mitchell, Bruce M Psaty, C Meisinger, C Sabatti, Caroline Hayward, Caroline S Fox, Charles C White, Christa Meisinger, Christie Ballantyne, Christopher J O'Donnell, Cornelia van Duijn, CS Fox, D Lloyd-Jones, D Wang, Daniel H O'Leary, David J Couper, DI Chasman, DI Chasman, E Falk, EB Mathiesen, Edward G Lakatta, Eran Halperin, Eric Boerwinkle, Eva-Maria Stoegerer, Fernando Rivadeneira, Florian Ernst, Georg Homuth, Gerardo Heiss, Gianluca Usala, Gonçalo R Abecasis, Gudny Eiriksdottir, H Erich Wichmann, H Schunkert, H Yasuda, Helena Schmidt, Henry Völzke, Hugh S Markus, Jacqueline Witteman, James F Wilson, Jan Lüdemann, Jennifer E Huffman, Jens Baumert, Jerome I Rotter, JH Stein, Joachim Thiery, Jochen Seissler, Jorma Viikari, Joseph F Polak, Joshua C Bis, K Stark, K Yuan, Kari North, Katja E Petrovic, Kenneth Rice, Kent Taylor, L Adrienne Cupples, L Paternoster, Leena Peltonen, Lenore J Launer, M Kolz, M Oguri, Manuela Uda, Marco Orru, Marcus Dörr, Maryam Kavousi, Matthias Sitzer, Mika Kähönen, Muredach P Reilly, MW Lorenz, N Soranzo, Nora Franceschini, Norman Klopp, Olli Raitakari, P Greenland, Philip A Wolf, Philipp S Wild, R Nakov, R Ross, Ralph B D'Agostino, Ravi Kumar Chilukoti, Reinhold Schmidt, Renate B Schnabel, S Kathiresan, S Kathiresan, Sekar Kathiresan, Serena Sanna, Serkalem Demissie, SH Johnsen, Stefan Blankenberg, Steve Bevan, Susan R Heckbert, T Rahman, TA Manolio, Tamara B Harris, Tanja Zeller, Terho Lehtimäki, Thomas Illig, Thomas Münzel, Thor Aspelund, Ulf Schminke, V Nambi, Vijay Nambi, Vilmundur Gudnason, W Insull Jr., Wendy S Post, Wolfgang Koenig, Wolfgang Rathmann, Xia Li, XZ Zhou, YS Aulchenko, Yu-Ching Cheng   +128 more
core   +2 more sources

Long‐Tea‐CLIP: An Expert‐Level Multimodal AI Framework for Fine‐Grained Green Tea Grading Across Five Sensory Dimensions

Advanced Science, EarlyView.
Long‐Tea‐CLIP (Contrastive Language‐Image Pre‐training) presents a multimodal AI framework that integrates visual, metabolomic, and sensory knowledge to grade green tea across appearance, soup color, aroma, taste, and infused leaf. By combining expert‐guided modeling with CLIP‐supervised learning, the system delivers fine‐grained quality evaluation and
Yanqun Xu, Zhengfang Xue, Qing Luo, Xu Liu, Yongquan Xu, Jing Huang, Xingcai Zhang, Xinyuan Zhang, Zhonghua Liu, Zisheng Luo   +9 more
wiley   +1 more source

Developmental dyslexia: Genetic dissection of a complex cognitive trait [PDF]

, 2002
Developmental dyslexia, a specific impairment of reading ability despite adequate intelligence and educational opportunity, is one of the most frequent childhood disorders.
DeFries, J., Fisher, S.
core   +2 more sources