Results 91 to 100 of about 1,730,968 (259)

Sociodemographic differences in symptom severity and duration among women referred to secondary care for menorrhagia in England and Wales: a cohort study from the National Heavy Menstrual Bleeding Audit. [PDF]

, 2018
OBJECTIVE: To examine symptom severity and duration at time of referral to secondary care for heavy menstrual bleeding (HMB) by socioeconomic deprivation, age and ethnicity DESIGN: Cohort analysis of data from the National HMB Audit linked to Hospital ...
Bansi-Matharu, Loveleen, Cromwell, David A, Geary, Rebecca Sally, Gurol-Urganci, Ipek, Kiran, Amit, Mahmood, Tahir, Shakespeare, Judy, van der Meulen, Jan   +7 more
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cost–utility analysis of adapted problem adaptation therapy for depression in mild-to-moderate dementia caused by Alzheimer's disease: PATHFINDER randomised controlled trial

BJPsych Open
Background Depression is common in people with dementia, and negatively affects quality of life. Aims This paper aims to evaluate the cost-effectiveness of an intervention for depression in mild and moderate dementia caused by Alzheimer's disease over ...
Monica Panca, Robert Howard, Elizabeth Cort, Charlotte Rawlinson, Rebecca L. Gould, Martin Wiegand, Anne Marie Downey, Sube Banerjee, Chris Fox, Rowan Harwood, Gill Livingston, Esme Moniz-Cook, Gregor Russell, Alan Thomas, Philip Wilkinson, Nick Freemantle, Rachael Maree Hunter   +16 more
doaj   +1 more source

Cost-Effectiveness of Point-of-Care C-Reactive Protein Tests for Respiratory Tract Infection in Primary Care in England [PDF]

, 2015
Introduction Despite recommendations that general practitioners (GPs) delay antibiotic prescribing for respiratory tract infections (RTIs), antibiotic prescriptions in primary care in England increased by 4.1% from 2010 to 2013.
Hunter, R
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

QALY losses for non-communicable diseases in Iranian adults: insights from a national cross-sectional study

Population Health Metrics
Background Non-communicable diseases (NCDs), constitute a major global public health challenge and represent the primary causes of mortality and morbidity worldwide. This study aims to estimate Quality-Adjusted Life Year (QALY) losses associated with six
Abdoreza Mousavi, Satar Rezaei, Ali Akbari Sari, Mohammad Amin Masoumi, Rajabali Daroudi   +4 more
doaj   +1 more source

Oral splints for patients with temporomandibular disorders or bruxism: a systematic review and economic evaluation

Health Technology Assessment, 2020
Background: Splints are a non-invasive, reversible management option for temporomandibular disorders or bruxism. The clinical effectiveness and cost-effectiveness of splints remain uncertain.
Philip Riley, Anne-Marie Glenny, Helen V Worthington, Elisabet Jacobsen, Clare Robertson, Justin Durham, Stephen Davies, Helen Petersen, Dwayne Boyers   +8 more
doaj   +1 more source

Cost-effectiveness of primary debulking surgery when compared to neoadjuvant chemotherapy in the management of stage IIIC and IV epithelial ovarian cancer. [PDF]

, 2016
ObjectivesTo examine the cost-effectiveness of primary debulking surgery (PDS) when compared to neoadjuvant chemotherapy (NACT) in the management of epithelial ovarian cancer (EOC) using Surveillance, Epidemiology, and End Results data linked to Medicare
Chang, Jenny, Forde, Gareth K, Ziogas, Argyrios   +2 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Medical costs and quality-adjusted life years associated with smoking: a systematic review

BMC Public Health, 2016
Background Estimated medical costs (“T”) and QALYs (“Q”) associated with smoking are frequently used in cost-utility analyses of tobacco control interventions.
Shari P. Feirman, Allison M. Glasser, Lyubov Teplitskaya, David R. Holtgrave, David B. Abrams, Raymond S. Niaura, Andrea C. Villanti   +6 more
doaj   +1 more source