Results 81 to 90 of about 1,728,317 (301)

The consequences of delaying insulin initiation in UK type 2 diabetes patients failing oral hyperglycaemic agents: a modelling study [PDF]

, 2009
Background Recent data have shown that type 2 diabetes patients in the UK delay initiating insulin on average for over 11 years after first being prescribed an oral medication.
Gordon Goodall, Eric M Sarpong, Clarice Hayes, William J Valentine, American Diabetes Association, B Jonsson, R Williams, A Liebl, D Wanless, Y Ohkubo, The DCCT Research Group, The UK Prospective Diabetes Study Group, The UK Prospective Diabetes Study Group, The Diabetes Control and Complications Trial-Epidemiology of Diabetes Interventions and Complications Research Group, ML Lawson, IM Stratton, The ADVANCE Collaboration Group, E Selvin, American Diabetes Association, HC Gerstein, DM Nathan, DG Marrero, MJ Calvert, MJ Calvert, AJ Palmer, AJ Palmer, P Clarke, C Mathers, TO Tengs, National Institute for Clinical Excellence, RR Holman, H Yki-Jarvinen, MN Cook, A Rubino, LG Mellbin, K Malmberg, SL Bowker, LG Hemkens, U Smith, SH Saydah, GT Higgins, C Bebb, M Peyrot, A Phillips   +43 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Productivity and quality-adjusted life years: QALYs, PALYs and beyond

, 2023
We develop a unified framework for the measurement and valuation of health and productivity. Within this framework, we characterize evaluation functions allowing for compromises between the classical quality-adjusted life years (QALYs) and its polar productivity-adjusted life years (PALYs).
Schultz Hansen, Kristian, Moreno-Ternero, Juan D., Østerdal, Lars Peter   +2 more
openaire   +3 more sources

QALYs, Person Trade-Offs, and the Pareto Principle. [PDF]

A considerable literature seems to argue the use of person trade-offs to estimate the quality-adjustment factor in Quality-Adjusted Life Years (QALY) models. A similar practise is followed by the WHO to estimate the disability weights used in calculation
Lars Peter Østerdal
core  

Cost-Effectiveness of Strategies to Improve HIV Testing and Receipt of Results: Economic Analysis of a Randomized Controlled Trial [PDF]

, 2010
The CDC recommends routine voluntary HIV testing of all patients 13-64 years of age. Despite this recommendation, HIV testing rates are low even among those at identifiable risk, and many patients do not return to receive their results.
Gillian D. Sanders, Henry D. Anaya, Steven Asch, Tuyen Hoang, Joya F. Golden, Ahmed M. Bayoumi, Douglas K. Owens, BM Branson, PM Wortley, G Marks, Centers for Disease Control and Prevention, HI Hall, A Qaseem, AD Paltiel, AD Paltiel, GD Sanders, GD Sanders, DK Owens, G Tao, AB Hutchinson, HD Anaya, MC Weinstein, JR Beck, FA Sonnenberg, BA Koblin, AN Phillips, JT King Jr, PS Rosenberg, JM Karon, JM Karon, DG Fryback, J Atri, VA Cargill, VL Champion, JJ Gonzalez, J Robson, EG Stone, CA Metcalf, SB Lyss, WJ Kassler, JS Haukoos, A Silva, PG Farnham, SD Mehta, RP Walensky, JL Greenwald, PG Yeni   +46 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

The STAR trial protocol: a randomised multi-stage phase II/III study of Sunitinib comparing temporary cessation with allowing continuation, at the time of maximal radiological response, in the first-line treatment of locally advanced/metastatic Renal Cancer

BMC Cancer, 2012
Background Over recent years a number of novel therapies have shown promise in advanced renal cell carcinoma (RCC). Internationally the standard of care of first-line therapy is sunitinib™, after a clear survival benefit was demonstrated over interferon ...
Collinson Fiona J, Gregory Walter M, McCabe Chris, Howard Helen, Lowe Catherine, Potrata DrBarbara, Tubeuf Sandy, Hanlon Pat, McParland Lucy, Wah T, Selby Peter J, Hewison Jenny, Brown Julia, Brown Janet   +13 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The concept of quality of life in oncology [PDF]

Archive of Oncology, 2004
Osoba David
doaj   +1 more source