Results 91 to 100 of about 21,139,354 (341)

Palliative ICU beds for potential organ donors: an effective use of resources based on quality-adjusted life-years gained.

Critical Care and Resuscitation, 2016
OBJECTIVE To evaluate whether the admission of a palliative patient to the intensive care unit for end-of-life care and consideration of organ donation provides an equivalent net benefit in quality-adjusted life-years (QALYs) compared with the admission ...
L. Nunnink, D. Cook
semanticscholar   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Utility and quality-adjusted life-years in coronary artery disease

Medicine, 2017
Objectives: This study evaluated the utility and quality-of-life year measurements for patients with coronary artery disease who underwent any of 3 therapeutic strategies with a 5-year follow-up.
S. Brandão, W. Hueb, Yang-Ting Ju, A. C. D. de Lima, C. Polanczyk, L. Cruz, R. Garcia, M. Takiuti, E. Bocchi   +8 more
semanticscholar   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Health economics evaluation of screening for sarcopenia among community-dwelling older persons

BMC Public Health
Objective Sarcopenia increased the risk of various adverse outcomes, including cardiovascular diseases, falls, and mortality. Implementing interventions could mitigate the harm caused by sarcopenia.
Yang Liu, Boran Sun, Jingyue Wang, Zhanliang Ruan, Yuan Wang, Jian Sun, Shu Wang, Wenli Lu   +7 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Measuring health and subjective wellbeing: vale, quality-adjusted life-years

, 2005
Measuring health and subjective wellbeing: vale, quality-adjusted life ...
Robert Cummins (13065627)
core  

QALY: Quality Adjusted Life Year

Medicine Science | International Medical Journal, 2012
Nufusun yaslanmasi ve yaslilik donemi hastaliklar ile kronik hastaliklarin one cikmasi verilen saglik hizmetlerinin sadece saglik duzeyi uzerine degil yasam kalitesine etkisinin de onemli bir cikti olarak degerlendirilmesini getirmistir. Aslinda bu yaklasim Dunya Saglik Orgutunun (WHO), 1946 yilinda sagligi “yalnizca hastalik ve sakatligin ...
Selale Sahin, Selime Toprak, Erdinc Unal
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

The Relationship between Urinary Incontinence Quality of Life and Sleep Quality in Women Over the Age of 60 Years

, 2020
Aim: The study aimed to investigate the relationship between urinary incontinence quality of life and sleep quality in women over the age of 60 ...
Özlem Örsal, ÜNVER, GAMZE, Pınar Duru, ÖRSAL, ÖZLEM, DURU, PINAR, Gamze Ünver   +5 more
core   +1 more source