Results 91 to 100 of about 586,644 (327)
Fundamental Measurement and Quality-Adjusted Life Years [PDF]
Value in Health, 2021 Paul C Langley, Stephen P. McKenna
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YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Surgery Open Science, 2020 Background: Transversus abdominis plane block with liposomal bupivacaine has been studied as an effective method of reducing the need for postoperative opioids and increasing same-day discharge rates.
Alexander L. Colonna +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Problems and solutions in calculating quality-adjusted life years (QALYs).
Health and quality of life outcomes, 2003 The quality-adjusted life-year (QALY) is a measure of the value of health outcomes. Since health is a function of length of life and quality of life, the QALY was developed as an attempt to combine the value of these attributes into a single index number. The QALY calculation is simple: the change in utility value induced by the treatment is multiplied
José A. Sacristán, Luis Prieto
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Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
ESC Heart FailureAims The long‐term cost‐effectiveness of MitraClip in heart failure patients with secondary mitral regurgitation is still unclear. This study aimed to evaluate the long‐term cost‐effectiveness of MitraClip added to guideline‐directed medical therapy vs ...
Younan Yao +7 more
doaj +1 more source
Indian Journal of Community MedicineBackground: Anti-Retroviral therapy for HIV/AIDS has been effective, but the mortality rate remains to be high, resulting in the use of second line of ART treatment for better results.
Anand Nandita +3 more
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High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer
FEBS Open Bio, EarlyView.Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson +5 more
wiley +1 more source
Health Technology Assessment, 2010 Objectives: To identify characteristics of beneficiaries of health care over which relative weights should be derived and to estimate relative weights to be attached to health gains according to characteristics of recipients of these gains (relativities ...
R Baker +14 more
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