Results 61 to 70 of about 1,647,697 (336)

The Proposal and Application of Quality-adjusted Life Years

Yixue yu zhexue
Quality-adjusted life years (QALYs) is a quantitative health measure that integrates both life expectancy and quality, proposed in the 1970s as an effective tool for aiding the rational allocation of healthcare resources while balancing efficiency and ...
Yixuan LI
doaj   +1 more source

A narrative review on the burden of migraine: when the burden is the impact on people’s life

The Journal of Headache and Pain, 2019
Background The burden of headache disorders, and of migraine in particular, is multifaceted and fragmented. The aim of this narrative review is to provide a description the main topics underlying the concepts of burden and impact of migraine disorders ...
Matilde Leonardi, Alberto Raggi
doaj   +1 more source

Economic burden on stroke survivors in Asian and African countries: A protocol for systematic review, meta-analysis, and meta-regression

International Journal of Noncommunicable Diseases, 2023
Introduction: Stroke is one of the leading causes of morbidity and mortality worldwide accompanied by huge financial burden on an individual and society.
Summaiya Zareen Shaikh, Anant Patil, Mohammed Usman Ali, Asmita Karajgi   +3 more
doaj   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Cost-effectiveness of individualized nutrition and exercise therapy for rehabilitation following hip fracture [PDF]

, 2016
OBJECTIVE: To undertake a cost-utility analysis of the Individual Nutrition Therapy and Exercise Regime: A Controlled Trial of Injured, Vulnerable Elderly (INTERACTIVE) trial. DESIGN: Cost-utility analysis of a randomized controlled trial.
Cameron, Ian D, Crotty, Maria, Kurrie, Susan, Mackintosh, Shylie, Miller, Michelle Deanne, Milte, Rachel, Ratcliffe, Julie, Thomas, Susan, Whitehead, Craig Hamilton   +8 more
core   +2 more sources

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Commentary on the Urgent Need for Comprehensive Cost-Effectiveness Studies in Temporomandibular Disorders

Journal of the California Dental Association
Objective This commentary underscores the critical need for focused, comprehensive research on the cost-effectiveness of treatments for temporomandibular disorders (TMD). While some studies have explored this area, a notable gap in systematic evaluations
K. Davina Frick, Anisha Paul-Ledesma
doaj   +1 more source

Valuing the benefit of varicella vaccination: comparison of willingness to pay and quality-adjusted life-years [PDF]

, 2004
Vaccination is different from most health interventions because it is preventative, it protects against infectious disease (leading to knock-on effects), the diseases it prevents are usually acute and self-limiting, and most vaccines are given to ...
Brisson, M., Edmunds, J.
core  

Socio-demographic characteristics, lifestyle factors and burden of morbidity associated with self-reported hearing and vision impairments in older British community-dwelling men: a cross-sectional study. [PDF]

, 2015
BACKGROUND: Hearing and vision problems are common in older adults. We investigated the association of self-reported sensory impairment with lifestyle factors, chronic conditions, physical functioning, quality of life and social interaction.
Carvalho, LA, Iliffe, S, Lennon, LT, Liljas, AEM, Papacosta, O, Ramsay, SE, Walters, K, Wannamethee, SG, Whincup, PH   +8 more
core   +2 more sources