Results 71 to 80 of about 1,728,986 (343)

The impact of childhood RSV infection on children's and parents' quality of life: a prospective multicenter study in Spain

BMC Infectious Diseases, 2021
Background  Several immunisation candidates against RSV are in late-stage clinical trials. To evaluate the benefits of a potential vaccination programme, both economic and health benefits will be needed.
Eva Díez-Gandía, Carla Gómez-Álvarez, Mónica López-Lacort, Cintia Muñoz-Quiles, Isabel Úbeda-Sansano, Javier Díez-Domingo, Alejandro Orrico-Sánchez, Study collaborators   +7 more
doaj   +1 more source

Association Between Sedentary Time and Quality of Life From the Osteoarthritis Initiative: Who Might Benefit Most From Treatment? [PDF]

, 2017
Objective To investigate the relationship between sedentary behavior and quality-adjusted life years (QALYs) among participants in the Osteoarthritis Initiative. Design Longitudinal, observational design.
Chang, Rowland W., Dunlop, Dorothy D., Ehrlich-Jones, Linda S., Lee, Jungwha, Pellegrini, Christine A., Pinto, Daniel, Semanik, Pamela A., Song, Jing   +7 more
core   +1 more source

The consequences of delaying insulin initiation in UK type 2 diabetes patients failing oral hyperglycaemic agents: a modelling study [PDF]

, 2009
Background Recent data have shown that type 2 diabetes patients in the UK delay initiating insulin on average for over 11 years after first being prescribed an oral medication.
Gordon Goodall, Eric M Sarpong, Clarice Hayes, William J Valentine, American Diabetes Association, B Jonsson, R Williams, A Liebl, D Wanless, Y Ohkubo, The DCCT Research Group, The UK Prospective Diabetes Study Group, The UK Prospective Diabetes Study Group, The Diabetes Control and Complications Trial-Epidemiology of Diabetes Interventions and Complications Research Group, ML Lawson, IM Stratton, The ADVANCE Collaboration Group, E Selvin, American Diabetes Association, HC Gerstein, DM Nathan, DG Marrero, MJ Calvert, MJ Calvert, AJ Palmer, AJ Palmer, P Clarke, C Mathers, TO Tengs, National Institute for Clinical Excellence, RR Holman, H Yki-Jarvinen, MN Cook, A Rubino, LG Mellbin, K Malmberg, SL Bowker, LG Hemkens, U Smith, SH Saydah, GT Higgins, C Bebb, M Peyrot, A Phillips   +43 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Making Rasch decisions: The use of Rasch analysis in the construction of preference based health related quality of life instruments [PDF]

, 2008
Objective: To set out the methodological process for using Rasch analysis alongside traditional psychometric methods in the development of a health state classification that is amenable to valuation.
Brazier, J., Coyne, K., Tsuchiya, A., Yang, Y., Young, T.   +4 more
core   +2 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Impact of Inactivated Influenza Vaccination on Health‐Related Quality of Life Among Japanese Healthcare Workers

Immunity, Inflammation and Disease
Background Influenza vaccinations are recommended for healthcare workers (HCWs). Quantification of the personal risks of vaccination compared to vaccine benefits can help guide more accurate benefit‐risk assessment and cost‐effectiveness analysis of ...
Taito Kitano, Sayaka Yoshida
doaj   +1 more source

To be screened or not to be screened Modeling the consequences of PSA screening for the individual [PDF]

, 2012
Background:Screening with prostate-specific antigen (PSA) can reduce prostate cancer mortality, but may advance diagnosis and treatment in time and lead to overdetection and overtreatment.
Bangma, C.H. (Chris), Draisma, G. (Gerrit), Heijnsdijk, E.A.M. (Eveline), Hugosson, J. (Jonas), Koning, H.J. (Harry) de, Wever, E.M. (Elisabeth)   +5 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Cost-Utility Analysis of Colorectal Cancer Screening Starting at Age 45 Compared to Age 50 in Colombia

Revista Colombiana de Gastroenterología
Background: Colorectal cancer (CRC) is among the four cancers with the highest incidence and mortality in Colombia. CRC screening is currently recommended in national guidelines starting at age 50.
Gerardo Andrés Puentes Leal, Marcela Pérez Rodríguez , Esperanza Peña Torres   +2 more
doaj   +1 more source