Results 11 to 20 of about 3,493,135 (324)

Quality-by-Design-Based Development of a Voxelotor Self-Nanoemulsifying Drug-Delivery System with Improved Biopharmaceutical Attributes

Pharmaceutics, 2021
Low aqueous solubility and poor oral bioavailability are limiting factors in the oral delivery of voxelotor, an antisickling agent. To overcome these limitations, a voxelotor self-nanoemulsifying drug delivery system was developed.
Aristote B. Buya, Romano Terrasi, Jérémie K. Mbinze, Giulio G. Muccioli, Ana Beloqui, Patrick B. Memvanga, Véronique Préat   +6 more
doaj   +1 more source

UHPLC Enantiomer Resolution for the ɑ/β-Adrenoceptor Antagonist R/S-Carvedilol and Its Major Active Metabolites on Chiralpak IB N-5

Molecules, 2022
Carvedilol (CAR), a racemic lipophilic aryloxy propanolamine, acts as a selective α1-adrenoreceptor antagonist and a nonselective β-adrenoreceptor antagonist. CAR metabolism mainly produces three active metabolites: desmethyl carvedilol (DMC), 4′-hydroxy
Liza Samir, Rasha Hanafi, Sami El Deeb, Hilde Spahn-Langguth   +3 more
doaj   +1 more source

Design Space Approach for the Optimization of Green Fluidized Bed Granulation Process in the Granulation of a Poorly Water-Soluble Fenofibrate Using Design of Experiment

Pharmaceutics, 2022
In the pharmaceutical industry, the systematic optimization of process variables using a quality-by-design (QbD) approach is highly precise, economic and ensures product quality. The current research presents the implementation of a design-of-experiment (
Mohamed H. Fayed, Ahmed Alalaiwe, Ziyad S. Almalki, Doaa A. Helal   +3 more
doaj   +1 more source

Optimization and Evaluation of Poly(lactide-co-glycolide) Nanoparticles for Enhanced Cellular Uptake and Efficacy of Paclitaxel in the Treatment of Head and Neck Cancer

Pharmaceutics, 2020
The particle size (PS) and encapsulation efficiency (EE%) of drug-loaded nanoparticles (NPs) may inhibit their cellular uptake and lead to possible leakage of the drug into the systemic circulation at the tumor site.
Mohamed Haider, Amr Elsherbeny, Jayalakshmi Jagal, Anna Hubatová-Vacková, Iman Saad Ahmed   +4 more
doaj   +1 more source

QbD Consideration for Developing a Double-Layered Tablet into a Single-Layered Tablet with Telmisartan and Amlodipine

Pharmaceutics, 2022
The aim of this study was to develop a single-layered version of commercially available Twynstar® (Telmisartan + Amlodipine) double-layered tablets to improve the dosing convenience.
Joo-Eun Kim, Young-Joon Park
doaj   +1 more source

Quality-by-Design Is a Tool for Quality Assurance in the Assessment of Enantioseparation of a Model Active Pharmaceutical Ingredient

Pharmaceuticals, 2020
The design of experiments (DoE) is one of the quality-by-design tools valued in analytical method development, not only for cost reduction and time effectiveness, but also for enabling analytical method control and understanding via a systematic workflow,
Dina Aboushady, Maria Kristina Parr, Rasha S. Hanafi   +2 more
doaj   +1 more source

Selective Stability Indicating Liquid Chromatographic Method Based on Quality by Design Framework and In Silico Toxicity Assessment for Infigratinib and Its Degradation Products

Molecules, 2023
Infigratinib, a protein kinase inhibitor employed in the therapeutic management of cholangiocarcinoma, was subjected to various stress conditions, including hydrolytic (acidic and alkaline), oxidative, photolytic, and thermal stress, in accordance with ...
Awadh M. Ali, Mohammed M. Alanazi, Mohamed W. Attwa, Hany W. Darwish   +3 more
doaj   +1 more source

Quality-by-design in pharmaceutical development: From current perspectives to practical applications

Acta Pharmaceutica, 2021
Current pharmaceutical research directions tend to follow a systematic approach in the field of applied research and development. The concept of quality-by-design (QbD) has been the focus of the current progress of pharmaceutical sciences. It is based on,
Kovács Béla, Péterfi Orsolya, Kovács-Deák Boglárka, Székely-Szentmiklósi István, Fülöp Ibolya, Bába László-István, Boda Francisc   +6 more
doaj   +1 more source

Risk-Assessment-Based Optimization Favours the Development of Albumin Nanoparticles with Proper Characteristics Prior to Drug Loading

Pharmaceutics, 2022
Albumin nanocarrier research and development is a challenging area in the field of personalized medicine and in providing advanced therapeutic solutions.
Gábor Katona, Bence Sipos, Ildikó Csóka   +2 more
doaj   +1 more source

Evaluation of formulation variables on azithromycin nanoparticles prepared by emulsification solvent diffusion method using quality by design approach [PDF]

Pharmaceutical Sciences Asia, 2022
The study aims to investigate the effect of formulation variables on the characteristics of azithromycin (AZI) nanoparticles using a quality by design approach. AZI nanoparticles were prepared by the emulsification solvent diffusion method.
Nguyen-Thach Tung, Canh-Hung Nguyen, Huu-Manh Nguyen   +2 more
doaj   +1 more source