Results 91 to 100 of about 6,418,185 (279)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A controlled vocabulary and taxonomy for the submission of quality attributes for therapeutic proteins

AAPS Open
Structured product quality data offer tremendous promise to revolutionize the submission of drug applications. However, the quality attributes for biological products do not have a systematic naming taxonomy, and consequently this limit poses a critical ...
Joel T. Welch, Steven Kozlowski, Bazarragchaa Damdinsuren, Brian A. Roelofs   +3 more
doaj   +1 more source

Standardized methodology for calculating the cost of medical care funded by government sources

Фармакоэкономика
Background. Current challenges in healthcare include an increase in life expectancy and in medical care (MC) needs, thereby putting pressure on the limited resources of the Russian healthcare system.
M. A. Sdvizhkova, S. A. Kovaleva, D. V. Fedyaev, V. V. Omelyanovskiy   +3 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Machine learning for predicting functional outcomes in acute ischemic stroke: insights from a nationwide stroke registry

Scientific Reports
Accurately predicting the prognosis of patients with acute ischemic stroke at discharge remains highly challenging after active treatment. The aim of this retrospective nationwide registry-based study was to identify key predictors associated with ...
Taehoon Ko, Kanghyuk Lee, Yong Uk Kwon, Yu Ra Lee, So Young Han, Jae Sang Oh   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Regulatory and legal status of clinical guidelines and their role in the quality control of medical care in countries of the European Union, North America and Asia

Фармакоэкономика, 2019
Introduction. In 2016-2018, the approaches to the development and use of clinical guidelines in the Russian Federation underwent substantial changes. As part of this work, legal aspects of clinical guidelines were modified.
V. K. Fedyaeva, U. N. Dmitrieva, N. I. Juravleva, N. I. Juravlev, M. Yu. Kovaleva, A. S. Korobkina, O. A. Sukhorukikh, A. A. Pashkina   +7 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

CONTENT OF ESSENTIAL MINERAL ELEMENTS AND MEAT QUALITY TRAITS OF LARGE WHITE PIGS AND THEIR CROSSBREEDS MEAT

Животновъдни науки, 2015
The aim of this study was to determine the essential mineral elements and meat quality traits in large white (LW) breed, large white x yorkshire (LWxY) and large white x landrace (LWxL) crossbreeds pork. The concentrations of natrium, magnesium, calcium,
VILMA VALAITIENE, ALMANTAS SHIMKUS, ALDONA SHIMKIENĖ, JOLITA KLEMENTAVICHIUTE, GUODA STANYTE, ILONA PREIKSHIENE   +5 more
doaj  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source