Results 151 to 160 of about 4,188,222 (350)

Architectural Design Quality in Local Authority Private Finance Initiative Sheltered Housing Projects: The Development of an Evaluation Tool

, 2014
Ever since the 1990s, when the Private Finance Initiative (PFI) was developed as the primary method for delivering major public-sector capital projects in the UK, it has been severely criticised for the lack of design quality in the buildings that it ...
Sharma, Monika
core  

Quality-by-Design Approach to Process Intensification of Bioinspired Silica Synthesis

Characterizing nanomaterials is challenging due to their macromolecular nature, requiring suites of physicochemical analysis to fully resolve their structure.
Gregory Beaucage (3746887), Siddharth V. Patwardhan (1736512), Gemma-Louise Davies (1704919), Carlos Brambila (12406851), Kabir Rishi (5807669), Joseph R. H. Manning (9924882)   +5 more
core   +1 more source

Towards a kansei-based user modeling methodology for eco-design [PDF]

, 2013
We propose here to highlight the benefits of building a framework linking Kansei Design (KD), User Centered Design (UCD) and Eco-design, as the correlation between these fields is barely explored in research at the current time.
AOUSSAT, Améziane, BOUCHARD, Carole, RASAMOELINA, Francis   +2 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Integrating failure documentation with A3 template to improve product design quality [PDF]

, 2012
Design quality always has great impact on the competitive attribution of companies. Knowledge Management has become an important process which could help companies to accumulate the knowledge created in the past, and use it to solve the current problem ...
Zhu, Linjia
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Dynamic Learning Organisations Supporting Knowledge Creation for Competitive and Integrated Product Design [PDF]

, 2009
Organised by: Cranfield UniversityThis paper shows that learning strategies and a structured approach to turn organisations into learning organisms have a major influence on the success of engineering programs in general, and on integrated design ...
Riel, A., Tichkiewitch, S., Messnarz, R., Spork, G.   +3 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Paclitaxel loaded Capmul MCM and tristearin based nanostructured lipid carriers (NLCs) for glioblastoma treatment: screening of formulation components by quality by design (QbD) approach

Discover Nano
Paclitaxel (PTX), a naturally occurring diterpenoid isolated from Taxus brevifolia, is a first-line drug for the treatment of glioblastoma; however, it suffers from the disadvantages of poor water solubility and nonspecific biodistribution, which cause ...
Pooja Mittal, Madhav Singla, Smriti, Ramit kapoor, Dileep Kumar, Saurabh Gupta, Gaurav Gupta, Tanima Bhattacharya   +7 more
doaj   +1 more source

Quality-by-design of nanopharmaceuticals - a state of the art.

Nanomedicine : nanotechnology, biology, and medicine, 2017
T. Bastogne
semanticscholar   +1 more source