Results 151 to 160 of about 65,281,917 (246)

Quality by Design-Guided Development of Ketoprofen-Cationic Aspasomes Unlocks the Antifungal Potential of Repurposed Ketoprofen for Topical Therapy. [PDF]

Pharmaceuticals (Basel)
Eltabeeb MA, Albash R, Hassan M, Ahmed S, Agiba AM, El-Sheikh AAK, Aziz DE.   +6 more
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

PLGA-Based In Situ-Forming Implants, a Quality by Design Perspective. [PDF]

Pharmaceutics
Campos-Morales N, Cervantes-Pérez LG, Sánchez-Mendoza A, Sánchez-Aguilar M, Escobar-Chávez JJ, Martínez-Acevedo L, Galindo-Pérez MJ, Miranda-Calderon JE.   +7 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Analytical Quality-by-Design-Based Development of an ELISA for <i>In Vitro</i> Assessment of Human Tetanus Immunoglobulin Potency. [PDF]

J Microbiol Biotechnol
Son M, Cha B, Na Y, Koh H, Choi CW, Lee J, Yoon SJ, Jeon YJ.   +7 more
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

From quality indicator to quality measurement: design and implementation of an automated audit and feedback tool for chronic kidney disease in Belgian primary care. [PDF]

BMJ Health Care Inform
Soetaert J, Paredis L, Vaes B, Van den Wyngaert I, Van Pottelbergh G, Van den Bulck S.   +5 more
europepmc   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Quality by Design-Guided Transethosomal Gel of Donepezil Hydrochloride and Quercetin for Potential Alzheimer's Management: Stability-Indicating Eco-Compatible RP-HPLC Method. [PDF]

Drug Dev Res
Kumar A, Kaushik A, Devi A, Ankalgi AD, Ashawat MS, Alharbi HM, Amin M, Khojah AA, Ahmad S, Zaki MEA.   +9 more
europepmc   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source