Results 241 to 250 of about 8,759,542 (335)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Overcoming Challenges in the Determination of Fatty Acid Ethyl Esters in Post-Mortem Plasma Samples with the Use of Targeted Metabolomics and the Quality by Design Approach. [PDF]

Biomedicines
Dawidowska J, Jacyna-Gębala J, Wawrzyniak R, Kaliszan M, Markuszewski MJ.   +4 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Enhancing 3-acetyl-11-keto-β-boswellic acid skin permeation <i>via</i> nanostructured lipid carriers: integrating quality by design principles for risk estimation and optimization. [PDF]

Nanoscale Adv
Priya S, Desai VM, Singh H, Taliyan R, Singhvi G.   +4 more
europepmc   +1 more source

Quality by design-based optimization and HP-TLC densitometric standardization of <i>Theobroma cacao</i> L. extract as a nutraceutical supplement. [PDF]

Front Nutr
Muppayyanamath A, Harish DR, Mastiholimath V, Patil PP, Patil VS, Hegde HV, Roy S.   +6 more
europepmc   +1 more source

A quality by design HPLC method for cephalosporin analysis in pharmaceuticals and water samples with environmental impact assessment. [PDF]

Sci Rep
Alqahtani A, Alqahtani T, Al Fatease A, Tolba EH.   +3 more
europepmc   +1 more source

Quality by design based ecofriendly HPLC analytical method for simultaneous quantification of erastin and lenalidomide in mesoporous silica nanoparticles. [PDF]

Sci Rep
Gupta A, Rachana SP, Moorkoth S, Dhas N.
europepmc   +1 more source

Establishing a scalable perfusion strategy for the manufacture of CAR-T cells in stirred-tank bioreactors using a quality-by-design approach. [PDF]

Bioeng Transl Med
Hood T, Springuel P, Slingsby F, Sandner V, Geis W, Schmidberger T, Bevan N, Vicard Q, Hengst J, Dianat N, Rafiq QA.   +10 more
europepmc   +1 more source

A quality-by-design approach to develop abemaciclib solid lipid nanoparticles for targeting breast cancer cell lines. [PDF]

Ther Deliv
Chin B, Meng Lim W, Almurisi SH, Madheswaran T.   +3 more
europepmc   +1 more source