Results 251 to 260 of about 4,188,222 (350)

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Integrating analytical quality by design into bioanalytical method development: an HPLC-FLD method for quantification of alectinib in biological matrix. [PDF]

BMC Chem
Lee EJ, Koo N, Kim MJ, Lee KR, Chae YJ.
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Quality by Design for Preclinical In Vitro Assay Development. [PDF]

Pharm Stat
Jones J, Zhang B, Zhang X, Konings P, Hansson P, Backmark A, Serrano A, Künzel U, Novick S.   +8 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

A quality-by-design optimized LC method for navigating degradation kinetics and quantification of favipiravir in the presence of degradation products and manufacturing impurities. [PDF]

BMC Chem
Ibrahim AE, Farouk M, Alamir SG, Salman BI, Belal TS, El Deeb S, Al-Harrasi A.   +6 more
europepmc   +1 more source

Quality by Design-Guided Development of Hydrogel-Forming Microneedles for Transdermal Delivery of Enfuvirtide. [PDF]

ACS Appl Mater Interfaces
Li H, Vora LK, Anjani Q, Abraham AM, Cong Y, Moreno-Castellanos N, Ballana E, Riveira Muñoz E, Nevot M, Donnelly RF.   +9 more
europepmc   +1 more source

The interpretation-use argument- the essential ingredient for high quality assessment design and validation. [PDF]

Adv Health Sci Educ Theory Pract
Raymond J, Dai DW, McAllister S.
europepmc   +1 more source

Quality by design strategy of human mesenchymal stem/stromal cell drug products for the treatment of knee osteoarthritis. [PDF]

World J Stem Cells
Yu H, Zhang F, He YC, Zhang LS.
europepmc   +1 more source

Quality by Design (QbD)-Based Development of a Self-Nanoemulsifying Drug Delivery System for the Ocular Delivery of Flurbiprofen. [PDF]

Pharmaceutics
Jeong JH, Yoon TH, Ryu SW, Kim MG, Kim GH, Oh YJ, Lee SJ, Kwak NW, Bang KH, Kim KS.   +9 more
europepmc   +1 more source