Results 21 to 30 of about 8,759,542 (335)

Quality engineering of a traction alternator by robust design [PDF]

, 2010
Robust design is an engineering methodology for improving productivity during research and development so that high-quality products can be developed and produced quickly and at low cost. A large electrical company was developing traction alternators for
E V Gijo, Hunter J. S., J Antony, Kackar R. N., Lucas J. M., Myers R. H., Myers R. H., Phadke M. S., Rao C. R., Taguchi G., Taguchi G., Taguchi G., U H Acharya, Welch W. J., Wu C. F. J.   +14 more
core   +1 more source

Quality by Design Approach for a Multicomponent Quantification Using HPLC-PDA and HPLC-MS: Application to Dosage Form and Biological Body Fluids

Separations, 2022
A multicomponent pharmaceutical that contains loratadine, paracetamol, and pseudoephedrine was quantified using HPLC-PDA. The three analytes were well-separated and quantified in the dosage form on a C-18 column using a gradient mobile phase.
Naser F. Al-Tannak, Bashayer J. Al-Shatti, Abdullah S. Al Ali, A. Hemdan   +3 more
doaj   +1 more source

Design of Experiments (DoE) applied to Pharmaceutical and Analytical Quality by Design (QbD)

Brazilian Journal of Pharmaceutical Sciences, 2018
According to Quality by Design (QbD) concept, quality should be built into product/method during pharmaceutical/analytical development. Usually, there are many input factors that may affect quality of product and methods. Recently, Design of Experiments (
Isa Martins Fukuda, Camila Francini Fidelis Pinto, C. S. Moreira, Alessandro Morais Saviano, F. R. Lourenço   +4 more
semanticscholar   +1 more source

Quality by Design Approach for Development and Characterization of Granisetron Hydrochloride-Loaded Orodispersible Films

Pharmaceutical Fronts, 2023
Granisetron hydrochloride can be used to prevent and treat nausea and vomiting induced by chemotherapy. Its prolonged half-life and reduced dose requirement improve patient acceptance. However, patients undergoing chemotherapy often suffer from dysphagia
Ming-Yan Li, Bing Wang, Jun-Qi Zhang, Liu-Liu Yang, Jun-Tao He, Fang Chen   +5 more
doaj   +1 more source

HPLC method development for fampridine using Analytical Quality by Design approach

Acta Pharmaceutica, 2020
Offering a systematic and multivariate analysis of the analytical procedure, development and validation of HPLC methods using Quality by Design approach are in the limelight of current research trends.
Kovács Béla, Boda Francisc, Fülöp Ibolya, Székely-Szentmiklósi István, Kelemen Éva Katalin, Kovács-Deák Boglárka, Székely-Szentmiklósi Blanka   +6 more
doaj   +1 more source

Analytical quality-by-design approach for development and validation of HPLC method for the simultaneous estimation of omarigliptin, metformin, and ezetimibe: application to human plasma and dosage forms

BMC Chemistry, 2023
A simple, selective, and sensitive RP-HPLC method was proposed for the simultaneous determination of two co-administered antidiabetic drugs (omarigliptin and metformin) with an anti-hyperlipidemic drug (ezetimibe) in a medicinally-recommended ratio of 2 ...
Galal Magdy, Amira A. Al-enna, Fathalla Belal, Ramadan A. El-Domany, Ahmed M. Abdel-Megied   +4 more
doaj   +1 more source

Formulation Approaches for Improving the Dissolution Behavior and Bioavailability of Tolvaptan Using SMEDDS

Pharmaceutics, 2022
Tolvaptan, a selective vasopressin receptor antagonist, is a Class IV agent of Biopharmaceutical Classification System (BCS). To improve bioavailability after oral administration, the new tolvaptan-loaded self-microemulsifying drug delivery system ...
Jong-Hwa Lee, Gye-Won Lee
doaj   +1 more source

Implications of customer participation in outsourcing noncore services to third parties [PDF]

, 2020
Purpose Focal service providers increasingly involve customers in the decision-making about outsourcing parts of the service delivery process to third parties.
De Pourcq, Kaat, Gemmel, Paul, Larivière, Bart, Trybou, Jeroen, Verleye, Katrien   +4 more
core   +3 more sources

Development of a robust and reliable reverse-phase high-performance liquid chromatography (RP-HPLC) method using analytical quality by design principles for the accurate determination of esculin in its bulk form

Future Journal of Pharmaceutical Sciences, 2023
Background Analytical quality by design is a proactive, holistic, and data-driven approach to quality that emphasizes risk assessment and management. This can lead to more robust and reliable methods than traditional approaches.
Sarvesh Patil, Anjana Adhyapak, Priya Shetti, Rohan Gurao   +3 more
doaj   +1 more source

Quality by Design Approach Using Multiple Linear and Logistic Regression Modeling Enables Microemulsion Scale Up

Molecules, 2019
The development of pharmaceutical nanoformulations has accelerated over the past decade. However, the nano-sized drug carriers continue to meet substantial regulatory and clinical translation challenges.
Michele Herneisey, Eric Lambert, Allison Kachel, Emma Shychuck, James K. Drennen, Jelena M. Janjic   +5 more
doaj   +1 more source