Results 31 to 40 of about 4,188,222 (350)

Design of Experiments (DoE) applied to Pharmaceutical and Analytical Quality by Design (QbD)

Brazilian Journal of Pharmaceutical Sciences, 2018
According to Quality by Design (QbD) concept, quality should be built into product/method during pharmaceutical/analytical development. Usually, there are many input factors that may affect quality of product and methods. Recently, Design of Experiments (
Isa Martins Fukuda, Camila Francini Fidelis Pinto, C. S. Moreira, Alessandro Morais Saviano, F. R. Lourenço   +4 more
semanticscholar   +1 more source

HPLC method development for fampridine using Analytical Quality by Design approach

Acta Pharmaceutica, 2020
Offering a systematic and multivariate analysis of the analytical procedure, development and validation of HPLC methods using Quality by Design approach are in the limelight of current research trends.
Kovács Béla, Boda Francisc, Fülöp Ibolya, Székely-Szentmiklósi István, Kelemen Éva Katalin, Kovács-Deák Boglárka, Székely-Szentmiklósi Blanka   +6 more
doaj   +1 more source

Analytical quality-by-design approach for development and validation of HPLC method for the simultaneous estimation of omarigliptin, metformin, and ezetimibe: application to human plasma and dosage forms

BMC Chemistry, 2023
A simple, selective, and sensitive RP-HPLC method was proposed for the simultaneous determination of two co-administered antidiabetic drugs (omarigliptin and metformin) with an anti-hyperlipidemic drug (ezetimibe) in a medicinally-recommended ratio of 2 ...
Galal Magdy, Amira A. Al-enna, Fathalla Belal, Ramadan A. El-Domany, Ahmed M. Abdel-Megied   +4 more
doaj   +1 more source

Formulation Approaches for Improving the Dissolution Behavior and Bioavailability of Tolvaptan Using SMEDDS

Pharmaceutics, 2022
Tolvaptan, a selective vasopressin receptor antagonist, is a Class IV agent of Biopharmaceutical Classification System (BCS). To improve bioavailability after oral administration, the new tolvaptan-loaded self-microemulsifying drug delivery system ...
Jong-Hwa Lee, Gye-Won Lee
doaj   +1 more source

Development of a robust and reliable reverse-phase high-performance liquid chromatography (RP-HPLC) method using analytical quality by design principles for the accurate determination of esculin in its bulk form

Future Journal of Pharmaceutical Sciences, 2023
Background Analytical quality by design is a proactive, holistic, and data-driven approach to quality that emphasizes risk assessment and management. This can lead to more robust and reliable methods than traditional approaches.
Sarvesh Patil, Anjana Adhyapak, Priya Shetti, Rohan Gurao   +3 more
doaj   +1 more source

An evaluation tool for design quality: PFI sheltered housing [PDF]

, 2013
The complex procurement process entailed by the private finance initiative (PFI) means that clients need new capacities to manage their relationships with bidders and to assess project proposals if the desired level of design quality is to be achieved ...
Giddings, Bob, Jensen, Phil, Sharma, Monika, Jones, Paul   +3 more
core   +1 more source

Quality by Design Approach Using Multiple Linear and Logistic Regression Modeling Enables Microemulsion Scale Up

Molecules, 2019
The development of pharmaceutical nanoformulations has accelerated over the past decade. However, the nano-sized drug carriers continue to meet substantial regulatory and clinical translation challenges.
Michele Herneisey, Eric Lambert, Allison Kachel, Emma Shychuck, James K. Drennen, Jelena M. Janjic   +5 more
doaj   +1 more source

Investigating organizational quality improvement systems, patient empowerment, organizational culture, professional involvement and the quality of care in European hospitals: the 'Deepening our Understanding of Quality Improvement in Europe (DUQuE)' project. [PDF]

, 2010
BACKGROUND: Hospitals in European countries apply a wide range of quality improvement strategies. Knowledge of the effectiveness of these strategies, implemented as part of an overall hospital quality improvement system, is limited.
Andrew Thompson, Klazinga, Niek, Arah Onyebuchi A, Suñol, Rosa, Arah, O.A., Groene Oliver, Klazinga Niek, Charles Bruneau, Thompson, Andrew, Cordula Wagner, Klazinga, N., Groene, O., Wagner, C., Wagner, Cordula, Suñol Rosa, Arah, Onyebuchi A.., Onyebuchi A Arah, Arah, O. A., Thompson Andrew, Rosa Suñol, Deepening our Understanding of Quality Improvement in Europe Res, Sunol, R., Arah, Onyebuchi A, ?, ?, Niek Klazinga, null null, Oliver Groene, Bruneau, Charles, Wagner Cordula, Bruneau Charles, Arah, Onyebuchi A., Groene, Oliver, Suñol Sala, Rosa, Bruneau, C., Thompson, A.   +34 more
core   +1 more source

Green quality by design HPLC approach for the simultaneous determination of Bilastine and Montelukast

BMC Chemistry, 2023
For the simultaneous estimation of two co-formulated antihistaminic drugs (Bilastine and Montelukast), a novel and eco-friendly reversed-phase HPLC approach with both diode array and fluorescence detection modes was designed.
Aya Roshdy, Randa Abdel Salam, Ghada Hadad, Fathallah Belal, Heba Elmansi   +4 more
doaj   +1 more source

The development of an herbal material quality control strategy considering the effects of manufacturing processes

Chinese Medicine, 2019
Background Quality by design (QbD) is an advanced drug quality control concept that has been gradually implemented in the optimization of manufacturing processes of Chinese medicines.
Jingjing Pan, Siyuan He, Jiayao Zheng, Jingyuan Shao, Ning Li, Yunqi Gong, Xingchu Gong   +6 more
doaj   +1 more source