Results 51 to 60 of about 7,649,748 (300)

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

AQbD-novel strategy for analytical methods

Future Journal of Pharmaceutical Sciences
Background Analytical Quality by Design (AQbD) has emerged as a pivotal paradigm in the realm of analytical chemistry, revolutionizing the approach to method development and validation. This innovative strategy integrates principles of Quality by Design (
Amruta Bairagi, Rutuja Kothrukar, Hemant Chikhale, Sreya Kosanam, Laxmikant Borse   +4 more
doaj   +1 more source

An Experimental Design Approach to Quantitative Expression for Quality Control of a Multicomponent Antidiabetic Formulation by the HILIC Method

Molecules, 2022
A rapid and reproducible hydrophilic liquid chromatography (HILIC) process was established for concomitant determination of remogliflozin etabonate (RE), vildagliptin (VD), and metformin (MF) in a formulation.
Mahesh Attimarad, Katharigatta Narayanaswamy Venugopala, Muhammad S. Chohan, Marysheela David, Efren II Plaza Molina, Nagaraja Sreeharsha, Anroop Balachandran Nair, Christophe Tratrat, Abdulrahman Ibrahim Altaysan, Abdulmalek Ahmed Balgoname   +9 more
doaj   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

QbD driven targeted pulmonary delivery of dexamethasone-loaded chitosan microspheres: Biodistribution and pharmacokinetic study

Saudi Pharmaceutical Journal, 2023
Inhaling drugs, on the other hand, is limited mainly by the natural mechanisms of the respiratory system, which push drug particles out of the lungs or make them inefficient once they are there.
B.R. Asha, Prakash Goudanavar, G.S.N. Koteswara Rao, Kumaraswamy Gandla, N. Raghavendra Naveen, Shahnaz Majeed, Ravindran Muthukumarasamy   +6 more
doaj   +1 more source

Improving design and implementation of OO container-like component libraries [PDF]

, 2002
Object-oriented design is usually driven by three main reusability principles: step-by-step design, design for reuse and design with reuse. However, these principles tend to be just partially applied to the subsequent object-oriented implementation ...
Franch Gutiérrez, Javier, Marco Gómez, Jordi   +1 more
core   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

Photonic crystals for confining, guiding, and emitting light [PDF]

, 2002
We show that by using the photonic crystals, we can confine, guide, and emit light efficiently. By precise control over the geometry and three-dimensional design, it is possible to obtain high quality optical devices with extremely small dimensions. Here
Lončar, Marko, Painter, Oskar, Scherer, Axel, Vučković, Jelena, Yoshie, Tomoyuki   +4 more
core   +2 more sources

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Testability enhancement of a basic set of CMOS cells [PDF]

, 1994
Testing should be evaluated as the ability of the test patterns to cover realistic faults, and high quality IC products demand high quality testing. We use a test strategy based on physical design for testability (to discover both open and short faults ...
Bruls, Brzozowski, Champac, Ferguson, Galiay, Jayasumana, Kindu, Koeppe, Levitt, Liu, Maly, Maly, Rajsuman, Reddy, Reddy, Riera, Soden, Soden, Teixeira, Vierhaus, Zasio   +20 more
core   +3 more sources