Results 71 to 80 of about 7,649,748 (300)

Risperidone-Loaded Nasal Thermosensitive Polymeric Micelles: Quality by Design-Based Formulation Study

open access: yesPharmaceutics
The current research aims to develop thermosensitive polymeric micelles loaded with risperidone for nasal administration, emphasizing the added benefits of their thermosensitive behavior under nasal conditions.
Bence Sipos   +2 more
doaj   +1 more source

Inpatient Food Insecurity and Pediatric Hematology Oncology Hospitalization Outcomes

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Children with cancer and blood disorders are at risk for food insecurity (FI). We aimed to describe the association of inpatient food insecurity (IFI) and hospitalization outcomes among patients admitted to the pediatric hematology oncology service. Of 325 caregivers screened for IFI, 60 (18.6%) screened positive.
Joanna M. Robles   +4 more
wiley   +1 more source

What to Fix? Distinguishing between design and non-design rules in automated tools

open access: yes, 2017
Technical debt---design shortcuts taken to optimize for delivery speed---is a critical part of long-term software costs. Consequently, automatically detecting technical debt is a high priority for software practitioners.
Bellomo, Stephany   +3 more
core   +1 more source

Architectural Design Quality in Local Authority Private Finance Initiative Projects [PDF]

open access: yes, 2010
Since the 1990s, when the Private Finance Initiative was developed as the primary method for delivering major public capital projects, there has been concern about the quality of many of the products.
Giddings, Bob   +3 more
core  

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu   +8 more
wiley   +1 more source

The design research pyramid: a three layer framework [PDF]

open access: yes, 2007
To support knowledge-based design development, considerable research has been conducted from various perspectives at different levels. The research on knowledge-based design support systems, generic design artefact and design process modelling, and the ...
Duffy, Alexander, Wang, Wenjuan
core  

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee   +9 more
wiley   +1 more source

QbD green analytical procedure for the quantification of tolvaptan by utilizing stability indicating UHPLC method

open access: yesBMC Chemistry
For the first time a new QbD-assisted green stability indicating ultra-high-performance liquid chromatography (UHPLC) method was developed and validated for quantifying Tolvaptan.
Shadab Anwar Hashmi, Pallavi Alegete
doaj   +1 more source

A QbD Approach for the Formulation and Control of Triclabendazole in Uncoated Tablets: From Polymorphs to Drug Formulation

open access: yesPharmaceutics
Triclabendazole (TCB) is a well-established anthelmintic effective in treating fascioliasis, a neglected tropical disease. This study employs quality by design (QbD) to investigate the impact of TCB polymorphism and pharmacotechnical variables, from the ...
Lucas P. Muzi   +2 more
doaj   +1 more source

Software development for flexible pavement thickness design based on aastho and road note 31 [PDF]

open access: yes, 2009
Nowadays, road and surface failure has become a critical issue in our country on the flexible pavement which reflects to a bad quality and error during design stage.
Chang, Tun Hua
core  

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