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Latent variable modeling approaches to assist the implementation of quality-by-design paradigms in pharmaceutical development and manufacturing [PDF]
, 2013 With the introduction of the Quality-by-Design (QbD) initiative, the American Food and Drug Administration and the other pharmaceutical regulatory Agencies aimed to change the traditional approaches to pharmaceutical development and manufacturing ...
Tomba, Emanuele
core
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Journal of Advanced Pharmaceutical Technology & Research, 2015 The purpose of present study was to optimize rizatriptan (RZT) chitosan (CS) nanoparticles using ionic gelation method by application of quality by design (QbD) approach. Based on risk assessment, effect of three variables, that is CS %, tripolyphosphate
Ajinath Eknath Shirsat +1 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The lack of design quality focus in construction: a case for examining suitable design processes
, 2009 A large number of projects in UK construction now involve contractor-led design and are thus very different from the traditional approach which formed the basis of the original Royal Institute of British Architects (RIBA) Outline Plan of Work.
Walker, Alan +2 more
core
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Quality assurance strategy of pharmacy compounded drugs
Фармацевтичний журнал, 2019 Formulations and in-pharmacy preparation process of compounded drugs were being created for centuries, and seem to have no concerns regarding the quality, compatibility and stability during storage or usage.
O. A. Zdoryk
doaj +1 more source
Cheste Workers University s Textures: materiality as a quality in modern design
, 2022 Moreno Barberá's built work offers the possibility of investigating to what extent materiality is fundamental to achieving the idea of integral design characteristic of modern architecture.
Usó-Martín, Fernando +1 more
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
International Journal of Trend in Scientific Research and Development, 2019 In today’s increasingly competitive Higher Education (HE) market, academic jobs are more precarious than ever. The way academics do their day-to-day job is under increasing scrutiny, with their outputs measured through the rigid lens of performativity ...
Rowena Ulbrick, E. Pechenkina
semanticscholar +1 more source