Results 111 to 120 of about 4,188,222 (350)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Project Process Cards: A Self Evaluation Tool for Design Studio
, 2019 Industrial design education is about process rather than product. Design education requires students to follow particular paths for learning design practice during their journey to proposing design solutions.
Öztoprak, Aydın +5 more
core +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Quality by Design: Towards the One-Page Quality Portfolio
, 2008 This paper explores the concept of quality and finds that quality is not inherent in an activity or artefact but is an organisationally defined concept to be derived from attributes that are inherent.
McDonald, Craig
core
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
QbD-Based Formulation Development of Amiodarone Hydrochloride Tablet
PharmaceuticsBackground/Objectives: We conducted this study to develop a generic amiodarone tablet pharmaceutically equivalent to the reference drug. This development is crucial for securing a stable supply chain for this orphan drug, which currently faces domestic ...
Chae-Won Jeon, Ju-Hyun Yoon, Joo-Eun Kim
doaj +1 more source
Pharmaceutical Technology in Hospital Pharmacy, 2018 A simple, highly robust (quality by design (QbD) approach), precise and accurate method using high performance liquid chromatography coupled to mass spectrometry has been established for the simultaneous separation, identification and quantitation of a ...
Bihola Unnati +2 more
doaj +1 more source
Urban Design Competition versus Design Interactivity and Quality Judgment [Elektronisk resurs]
, 2011 The study is targeted to analyze the essence of interactive design process, design methodology and the communicability of quality judgment of urban design competitions.
Kazemian, Reza,
core
, 2020 Additive manufacturing facilitates the design of porous metal implants with detailed internal architecture. A rationally designed porous structure can provide to biocompatible titanium alloys biomimetic mechanical and biological properties for bone ...
Shoujin Sun +7 more
core +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source