Results 121 to 130 of about 4,188,222 (350)

Quality by Design Approach for Preparation of Zolmitriptan/Chitosan Nanostructured Lipid Carrier Particles – Formulation and Pharmacodynamic Assessment

International Journal of Nanomedicine, 2020
Randa Hanie Awadeen, Mariza Fouad Boughdady, Mahasen Mohamed Meshali Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura 35516, EgyptCorrespondence: Randa Hanie AwadeenDepartment of Pharmaceutics, Faculty of Pharmacy, Mansoura
Awadeen RH, Boughdady MF, Meshali MM
doaj  

Procedural Analog Design (PAD) tool

This paper presents a new Procedural Analog Design tool called PAD. It is a chart-based design environment dedicated to the design of analog circuits aiming to optimise design and quality by finding good tradeoffs.
Stefanovic, D., Litovski, V. B., Pastre, M., Kayal, M.   +3 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Quality by Design Considerations for Drop-on-Demand Point-of-Care Pharmaceutical Manufacturing of Precision Medicine

Distributed and point-of-care (POC) manufacturing facilities enable an agile pharmaceutical production paradigm that can respond to localized needs, providing personalized and precision medicine.
William , Feeney, Johnny, Ho, John Greg, Gillen, Thomas P, Forbes   +3 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Generic Diagramming Platform (GDP): a comprehensive database of high-quality biomedical graphics

Nucleic Acids Research
High-quality schematic illustrations are fundamental to the publication of scientific achievements in biomedical research, which are crucial for effectively conveying complex biomedical concepts.
Shuai Jiang, Huiqin Li, Luowanyue Zhang, Weiping Mu, Ya Zhang, Tianjian Chen, Jingxing Wu, Hao-Lin Tang, Shuxin Zheng, Yifei Liu, Yaxuan Wu, Xiaotong Luo, Yubin Xie, Jian Ren   +13 more
semanticscholar   +1 more source

Indicators for measuring satisfaction towards design quality of buildings

, 2016
Design quality is an important component in measuring satisfaction towards total product quality (TPQ) of buildings, the product of construction projects.
M.F, Abu Bakar, Suratkon, Azeanita, S.Y, Lim, Jusoh, Safuan, Chan, Chee Ming, Z.J, Tan, H, Sutimin   +6 more
core   +1 more source