Results 101 to 110 of about 4,188,222 (350)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

The culture and economics of urban public space design: public and professional perceptions

, 2009
Urban public space is once again a ‘hot’ topic and figures strongly in place quality discourse. City spaces are being recycled, reinterpreted and reinvented in a drive for a competitive quality of place.
Lee Pugalis, Pugalis, L, Pugalis, Lee
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Quality by Design (QbD)-Driven Development and Optimization of Tacrolimus-Loaded Microemulsion for the Treatment of Skin Inflammation

Pharmaceutics
Background: Skin inflammation represents a hallmark of many skin conditions, from psoriasis to eczema. Here, we present a novel microemulsion formulation for delivering a low dose of potent immunosuppressant, tacrolimus, to the skin for local ...
Sanjida Ahmed Srishti, Paromita Paul Pinky, Ryan Taylor, Jacob Guess, Natasha Karlik, Jelena M. Janjic   +5 more
doaj   +1 more source

Small Volume Dissolution Testing as a Powerful Method during Pharmaceutical Development

Pharmaceutics, 2010
Standard compendia dissolution apparatus are the first choice for development of new dissolution methods. Nevertheless, limitations coming from the amount of material available, analytical sensitivity, lack of discrimination or biorelevance may warrant ...
Eric Beyssac, Jean-Michel Cardot, Marc Lindenberg, Emmanuel Scheubel   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

QbD-guided HPTLC method development and validation for quantitative estimation of anticancer drugs

Journal of Applied Pharmaceutical Research
Background: Olaparib, Abiraterone acetate, and Pazopanib are critical anticancer agents used in the treatment of breast/ovarian, prostate, and renal cancers, respectively.
Bhavik Jani, Hitesh Vekariya
doaj   +1 more source

Quality-by-design for biotechnology-related pharmaceuticals.

Biotechnology Journal, 2009
The following article is a report from a workshop on Quality-by-Design (QbD) held at the 7th European Symposium on Biochemical Engineering Science (7 September 2008, Faro, Portugal).The aim of the workshop was to provide an update on the present status ...
C. Mandenius, K. Graumann, T. W. Schultz, A. Premstaller, Ing-Marie Olsson, E. Petiot, C. Clemens, M. Welin   +7 more
semanticscholar   +1 more source

Preliminary of User Interface Design for Picture Archiving and Communication System

, 2013
[[abstract]]In order to gain entry to modern and technology, medical imaging technology not only has to economically storing, and conveniently accessing, images from multiple modalities, but also focus on user’s experience and interaction.
Lin, Wei-Chun Winine;Lee, Yuan-Zone
core  

Modular product design and customization [PDF]

, 2009
Organised by: Cranfield UniversityThe paper deals with modular design architecture and its capabilities for easy and fast customization in products. The basic principles of modularity are mentioned and the most known methodologies and tools for modular
Chryssolouris, G., Pandremenos, J.
core