Results 81 to 90 of about 65,133,632 (292)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Quality assurance strategy of pharmacy compounded drugs

Фармацевтичний журнал, 2019
Formulations and in-pharmacy preparation process of compounded drugs were being created for centuries, and seem to have no concerns regarding the quality, compatibility and stability during storage or usage.
O. A. Zdoryk
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Coffee by Design Supports the Community

, 2019
Description of Coffee By Design\u27s Rebel Blend Fund Grant. Briefly describes Coffee by Design and the fund, which uses proceeds from the sale of the company\u27s Rebel Blend coffee to grant money to art projects in Maine.
Coffee by Design
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Investigating organizational quality improvement systems, patient empowerment, organizational culture, professional involvement and the quality of care in European hospitals: the 'Deepening our Understanding of Quality Improvement in Europe (DUQuE)' project. [PDF]

, 2010
BACKGROUND: Hospitals in European countries apply a wide range of quality improvement strategies. Knowledge of the effectiveness of these strategies, implemented as part of an overall hospital quality improvement system, is limited.
Andrew Thompson, Klazinga, Niek, Arah Onyebuchi A, Suñol, Rosa, Arah, O.A., Groene Oliver, Klazinga Niek, Charles Bruneau, Thompson, Andrew, Cordula Wagner, Klazinga, N., Groene, O., Wagner, C., Wagner, Cordula, Suñol Rosa, Arah, Onyebuchi A.., Onyebuchi A Arah, Arah, O. A., Thompson Andrew, Rosa Suñol, Deepening our Understanding of Quality Improvement in Europe Res, Sunol, R., Arah, Onyebuchi A, ?, ?, Niek Klazinga, null null, Oliver Groene, Bruneau, Charles, Wagner Cordula, Bruneau Charles, Arah, Onyebuchi A., Groene, Oliver, Suñol Sala, Rosa, Bruneau, C., Thompson, A.   +34 more
core   +4 more sources

Quality by Design (QbD)-Driven Development and Optimization of Tacrolimus-Loaded Microemulsion for the Treatment of Skin Inflammation

Pharmaceutics
Background: Skin inflammation represents a hallmark of many skin conditions, from psoriasis to eczema. Here, we present a novel microemulsion formulation for delivering a low dose of potent immunosuppressant, tacrolimus, to the skin for local ...
Sanjida Ahmed Srishti, Paromita Paul Pinky, Ryan Taylor, Jacob Guess, Natasha Karlik, Jelena M. Janjic   +5 more
doaj   +1 more source

Small Volume Dissolution Testing as a Powerful Method during Pharmaceutical Development

Pharmaceutics, 2010
Standard compendia dissolution apparatus are the first choice for development of new dissolution methods. Nevertheless, limitations coming from the amount of material available, analytical sensitivity, lack of discrimination or biorelevance may warrant ...
Eric Beyssac, Jean-Michel Cardot, Marc Lindenberg, Emmanuel Scheubel   +3 more
doaj   +1 more source