Results 51 to 60 of about 8,759,542 (335)

Cognitive Functioning in Vorinostat‐Treated Pediatric and Young Adult Patients Over the First 180 Days After Hematopoietic Stem Cell Transplant

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Cognitive and psychological difficulties could negatively interfere with treatment adherence and quality of life before and after hematopoietic stem cell transplant (HSCT). Methods to mitigate these changes may have positive effects on treatment success.
Kristen L. Votruba, Michelle Rozwadowski, Thomas Braun, April Rahrig, Edward Peres, Kirsten M. Williams, Vanessa Fabrizio, Julie‐An Talano, Carrie L. Kitko, Nicolas Parnell, Pavan Reddy, Sung Won Choi   +11 more
wiley   +1 more source

Evaluation of the Utility of Baseline Echocardiogram in Patients With Standard Risk Precursor B‐Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
Abstract Background A routine baseline echocardiogram is often obtained prior to anthracycline administration in children with cancer. The utility of baseline echocardiogram is unclear in patients with standard risk B‐cell acute lymphoblastic leukemia (SR B‐ALL) as their anthracycline cumulative dose is low.
Ziyad Alrajhi, Alice Pozza, Luc Mertens, Adam Paul Yan, Sarah Alexander   +4 more
wiley   +1 more source

Analytical Quality by Design

Brazilian Journal of Analytical Chemistry, 2021
Throughout the 20th century, the notion of ‘quality’ underwent major changes. The concept of ‘Quality by Testing’, i.e. evaluating the quality of a product by testing it for some pre-defined parameters after completing the manufacturing process, started to be replaced by the enhanced approach of Quality by Design (QbD).
openaire   +1 more source

Multi-objective design optimisation of a 3D-rail stamping process using a robust multi-objective optimisation platform (RMOP) [PDF]

, 2013
The paper investigates the multi-objective design optimisation of a stamping process to control the final shape and the final quality using advanced high strength steels. The design problem of the stamping process is formulated to minimise the difference
Coma Company, Martí, Espinoza Román, Héctor Gabriel, Fruitós Bickham, Óscar Alejandro, Lee, DongSeop, Pons Prats, Jordi   +4 more
core   +1 more source

Analytical Quality by Design: A Tool for Regulatory Flexibility and Robust Analytics

International Journal of Analytical Chemistry, 2015
Very recently, Food and Drug Administration (FDA) has approved a few new drug applications (NDA) with regulatory flexibility for quality by design (QbD) based analytical approach.
R. Peraman, K. Bhadraya, Y. Padmanabha Reddy   +2 more
semanticscholar   +1 more source

CPX‐351 in High‐Risk Relapsed Pediatric Acute Leukemia: Real‐World Phase 1 Data Establishing the FDA‐Approved Dose

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Outcomes for pediatric relapsed/refractory (R/R) acute myeloid leukemia (AML) remain dismal. CPX‐351, a liposomal formulation of cytarabine and daunorubicin, may have less off‐target toxicities than traditional chemotherapies and has shown improved outcomes for adults with newly diagnosed therapy‐related AML.
Jonathan D. Bender, Lauren Pommert, Lori R. Backus, Andrea Bidwell, Courtney Blank, Erin H. Breese, Karen C. Burns, Adam Lane, Lynn H. Lee, Benjamin Mizukawa, Robin E. Norris, Maureen M. O'Brien, Daniel Peck, Christine Phillips, Thomas D. Ryan, Jennifer Young, Michael Absalon, John P. Perentesis   +17 more
wiley   +1 more source

AQbD-novel strategy for analytical methods

Future Journal of Pharmaceutical Sciences
Background Analytical Quality by Design (AQbD) has emerged as a pivotal paradigm in the realm of analytical chemistry, revolutionizing the approach to method development and validation. This innovative strategy integrates principles of Quality by Design (
Amruta Bairagi, Rutuja Kothrukar, Hemant Chikhale, Sreya Kosanam, Laxmikant Borse   +4 more
doaj   +1 more source

An Experimental Design Approach to Quantitative Expression for Quality Control of a Multicomponent Antidiabetic Formulation by the HILIC Method

Molecules, 2022
A rapid and reproducible hydrophilic liquid chromatography (HILIC) process was established for concomitant determination of remogliflozin etabonate (RE), vildagliptin (VD), and metformin (MF) in a formulation.
Mahesh Attimarad, Katharigatta Narayanaswamy Venugopala, Muhammad S. Chohan, Marysheela David, Efren II Plaza Molina, Nagaraja Sreeharsha, Anroop Balachandran Nair, Christophe Tratrat, Abdulrahman Ibrahim Altaysan, Abdulmalek Ahmed Balgoname   +9 more
doaj   +1 more source

Influence of variability in starting materials quality on stability of finished drug products: a quality-by-design factor and response [PDF]

, 2012
The use of ill selected excipients in drug formulations can have a significant influence on the overall stability. Therefore, evaluation of chemical and physical excipient compatibility with the API has become a major part in the development of new drug ...
Bauters, Tieneke, D'Hondt, Matthias, De Spiegeleer, Bart, Robays, Hugo, Vandenbroucke, Johan, Wynendaele, Evelien   +5 more
core   +1 more source

Effect of process parameters and optimization of CO2 laser cutting of ultra high performance polyethylene [PDF]

, 2010
The aim of this work is to relate the cutting edge quality parameters (responses) namely: upper kerf, lower kerf, ratio of the upper kerf to lower kerf and cut edge roughness to the process parameters considered in this research and to find out the ...
A.G. Olabi, Caiazzo, Choudhury, Davim, Davim, H.A. Eltawahni, K.Y. Benyounis, Khuri, Kurt, Montgomery, Naceur, Olabi, Powell, Shuaeib   +13 more
core   +1 more source