Results 191 to 200 of about 3,065,151 (267)

Protocol for generation, time-course imaging, and automated quality control of 3D spheroid invasion using TRACEQC. [PDF]

STAR Protoc
Cramer EM, Lopez-Vidal T, Wang V, Johnson J, Bergman DR, Weeraratna AT, Fertig EJ, Heiser LM, Chang YH, Zimmerman JW.   +9 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Dietary Polyphenols in Aging: A Systems-Level Perspective on Mitochondrial Quality Control and Microbiome Interactions. [PDF]

Int J Mol Sci
Yılmaz A, Park HJ, Ahn EM, Bae J.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Explainable Artificial Intelligence for Coffee Quality Control: From Coffee Origins to Aroma Intensity. [PDF]

Foods
Felizzato G, Bagnulo E, Botta G, Tapparo G, Cordero C, Navarini L, Cagliero C, Liberto E, Caratti A.   +8 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Intersoftware variability in SPECT quality control: A technical note on analytical discrepancies and compliance decisions. [PDF]

J Appl Clin Med Phys
Jiawu F, Li Z, Shaojia W, Fei L, Yuhang C, Huaguang P, Xuan Z, Yongliang C, Jingzhi S.   +8 more
europepmc   +1 more source

Study on the effectiveness and accessibility of a CDR-based VTE quality control platform in county-level hospitals. [PDF]

BMJ Open Qual
Zang Z, Liu BS, Li J, Li L, Li Z, Liu J, Zhang J, Bian W, Yuan C, Wang M.   +9 more
europepmc   +1 more source