Results 221 to 230 of about 2,964,010 (315)

SpotSweeper: spatially aware quality control for spatial transcriptomics. [PDF]

Nat Methods
Totty M, Hicks SC, Guo B.
europepmc   +1 more source

Standardization and Quality Control of Ayurvedic Polyherbal Formulations

A. Y. Sahare, S. C. Akare, Rakesh Agrawal, Santosh Gotephode, Sachin A. Gajbhiye   +4 more
openalex   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The formation mechanism of high-quality clastic rock reservoir controlled by coupling of “structure-lithofacies-fluid” in the foreland thrust belt in northern Kuqa, Tarim Basin, Northwestern China

Hao Wang, Kelai Xi, Yingchang Cao, Xianzhang Yang, Ke-Yu Liu, Guoding Yu, Nianmin Zan, Yin Liu   +7 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Correction: Mitochondrial quality control in diabetes mellitus and complications: molecular mechanisms and therapeutic strategies. [PDF]

Cell Death Dis
Chen Y, Liu X, Liu Y, Li Y, Li D, Mei Z, Deng Y.   +6 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Quality control at the powerhouse: mitochondrial proteostasis dysfunction and disease. [PDF]

Biochem Soc Trans
Baker MJ, Yek KQ, Stojanovski D.
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Mitochondrial components secretion in extracellular vesicles promotes alveolar epithelial mitochondrial quality control. [PDF]

Nat Commun
Liu B, Han Y, Jin Y, Ye M, Yang Z, Yang J, Zhu M, Zhao X, Jin Y, Yin Y.   +9 more
europepmc   +1 more source