Results 81 to 90 of about 8,438,894 (311)
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Quality Prediction of Open Educational Resources A Metadata-based Approach [PDF]
arXiv, 2020 In the recent decade, online learning environments have accumulated millions of Open Educational Resources (OERs). However, for learners, finding relevant and high quality OERs is a complicated and time-consuming activity. Furthermore, metadata play a key role in offering high quality services such as recommendation and search.
arxiv
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source
Frontiers in Microbiology, 2018 Consumption of dietary protein at recommended levels is considered a potential strategy to promote satiety and weight management, but how protein from different dietary sources effect the obesity development, lipid metabolism, and gut microbiota is not ...
Muhammad Umair Ijaz +17 more
doaj +1 more source
Time-Energy Uncertainty Relation for a Quantum Clock as a Control Device [PDF]
arXiv, 2011 A quantum clock working as a control device is examined. The quality of the control process is characterized by the magnitude of deviation of perturbed state from unperturbed state of the controlled system. Uncertainty relations that relate the time duration of the process and energy of the clock to the quality of the control are presented.
arxiv
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
Fish oil, lard and soybean oil differentially shape gut microbiota of middle-aged rats
Scientific Reports, 2017 High-fat diets have been associated with overweight/obesity and increased mortality in middle-aged populations. However, it is still unclear how gut microbiota in middle-aged populations responds to dietary fats at a normal dose.
He Li +7 more
doaj +1 more source
A Technical Survey on Statistical Modelling and Design Methods for Crowdsourcing Quality Control [PDF]
arXiv, 2018 Online crowdsourcing provides a scalable and inexpensive means to collect knowledge (e.g. labels) about various types of data items (e.g. text, audio, video). However, it is also known to result in large variance in the quality of recorded responses which often cannot be directly used for training machine learning systems.
arxiv
Molecular Oncology, EarlyView.The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens +8 more
wiley +1 more source