Results 71 to 80 of about 18,201,096 (304)

Methodology of forming a model of diagnosis-related groups for cases of medical care using surgery performed by laparoscopic access

Фармакоэкономика
Background. A wide range of endosurgical treatment methods in various medical care profiles and the need for uniformity of calculations required developing a unified approach to the formation of diagnosis-related groups (DRGs) for cases of surgical ...
I. A. Zheleznyakova, O. A. Volkova, E. I. Rumiantseva, I. A. Mikhailov, D. V. Fedyaev, A. V. Zuev, O. S. Plakhotnik, G. V. Trifonova, T. S. Vakhrusheva, E. S. Samsonova, V. V. Omelyanovskiy   +10 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

401 Water quality certification

Water Boards Water Boards KRI STINE MURRAY, CHAIR I JAYNE J o y, EXECUTIVE OFFICER e GAVIN N EWSOM GOVfA NOR YANA GARCIA SECRETARY FOR ENVIRONMENTAL PROTECTION 3737 Main Street, Suite 500, Riverside, CA 92501-3348 I www.waterboards.ca.gov/santaana Santa ...
California Regional Water Quality Control Board;
core   +1 more source

Factors influencing sepsis associated thrombocytopenia (SAT): A multicenter retrospective cohort study.

PLoS ONE
IntroductionSepsis associated thrombocytopenia (SAT) is a common complication of sepsis. We designed this study to investigate factors influencing SAT.MethodsPatients with sepsis (2984 in Peking union medical college hospital [PUMCH] database, 13165 in ...
Lu Wang, Jieqing Chen, Xiang Zhou, China National Critical Care Quality Control Centre Group (China-NCCQC)   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Assessment of the impact of procurement centralization on the drug provision for patients within the High-Cost Nosology Program in the Russian Federation

Фармакоэкономика
Background. In the Russian Federation, patients receive expensive drugs from the federal budget funds within High-Cost Nosology (HCN) Program.Objective: to assess the impact of drug procurement centralization on the weighted average price (WAP) per 1 ...
V. V. Omelyanovskiy, V. A. Ryagina, A. G. Kharitonova, K. I. Matrenin, A. A. Kingshott, O. V. Ashikhmina, M. V. Zhirov   +6 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Economic analysis of implementing Systemic Coronary Risk Estimation (SCORE2) scale and long-term consequences

Фармакоэкономика
Objective: to assess the demand for pharmacotherapy in risk groups on adverse cardiovascular (CV) events identified during prophylactic medical examination of the adult population according to the SCORE2 (Systemic Coronary Risk Estimation) scale, which ...
E. O. Kurilovich, A. V. Nikitina, I. V. Sorokovikov   +2 more
doaj   +1 more source

Quality Control and Fidelity [PDF]

Developmental Cell, 2012
Like factories in miniature, cells must organize complex arrays of machinery into robust and accurate processes. It comes as no surprise, then, that diverse quality control and precision mechanisms underlie virtually all aspects of cellular function. In this issue, we are pleased to present a group of Review articles exploring facets of key cellular ...
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source