Results 101 to 110 of about 1,742,858 (300)

Manufacturing Execution Systems: Examples of Performance Indicator and Operational Robustness Tools

open access: yesCHIMIA, 2016
Manufacturing Execution Systems (MES) are computerized systems used to measure production performance in terms of productivity, yield, and quality.
Yannick Gendre   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

A method of prioritizing quality improvement in aviation refuelling services at airport

open access: yesAdvances in Mechanical Engineering, 2017
There has been growing emphasis on quality measures and process analysis techniques that may be implemented in the daily practice of aviation refuelling to improve the overall quality of safety care.
Kanon Ruamchat   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Evaluating the Stormwater Treatment Performance of AbTech Industries Smart Sponge® Plus, Landry, N [PDF]

open access: yes, 2004
The ability of AbTech’s Smart Sponge® Plus to remove fecal-borne bacteria from stormwater was evaluated in a storm drainage system located in Seabrook, New Hampshire.
Jones, Stephen H.   +2 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Quality Markers of Traditional Chinese Medicine: Concept, Progress, and Perspective

open access: yesEngineering, 2019
As the most important complementary medication against a variety of diseases, traditional Chinese medicines (TCMs) have been extensively applied over thousands of years. Current quality control of herbal medicines, however, is in great dispute.
Yazhuo Li   +5 more
doaj   +1 more source

EVALUATION OF MUNICIPAL SERVICES IN SELECTED WARDS OF DHAKA CITY CORPORATION: CITIZEN’S PERSPECTIVE [PDF]

open access: yes
Dhaka city is the home of more than five million and is one of the most densely populated cities of the world. Dhaka City Corporation is responsible for providing various services to its citizen with its limited resources. ‘Citizen Report Card’ is one of
Ishrat ISLAM   +2 more
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

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