Results 161 to 170 of about 2,480,610 (358)

Biofunctool®: a new set of indicators to assess the impact of land management onsoil functioning [PDF]

open access: yes, 2019
The concept and methods to assess soil quality have been widely debated in the literature for the last twenty years. We developed a new framework to assess soil quality following an integrative approach based on the measurement of soil dynamic functions ...
Bessou, Cécile   +7 more
core  

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Regional innovation measured by patent data – does quality matter? [PDF]

open access: yes
Patent data play an important role as indicators of inventive and innovative activity across regions. This paper examines if the geographical distribution changes and in what direction if patent data are quality-adjusted.
Ejermo, Olof
core  

Quality and Quality Indicators in Peritoneal Dialysis

open access: yes, 2011
Physicians have historically shared an intuitive concept of Quality, concerning the care we provide to our patients. Our academic education and practice have been focused on Quality as a technical concept, assessable only by technicians and with no strong correlation with outcomes. The concept of Medicine as an Art is related to the values of vocation,
openaire   +3 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

open access: yesMolecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Home - About - Disclaimer - Privacy