Results 131 to 140 of about 7,137,342 (353)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
PRINCIPLES OF TQM IN AUTOMOTIVE INDUSTRY [PDF]
TQM refers to a management process and set of disciplines that are coordinated to ensure thatthe organization consistently meets and exceeds customer requirements. TQM engages all divisions,departments and levels of the organization.
Isac Nicoleta
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Next NanotechnologyIn the realm of nanotechnology, carbon-based materials stand as a testament to how nature's simplest element can inspire boundless innovation. However, challenges including defect-free synthesis, high production costs, purification or separation ...
Aruna Yadav +5 more
doaj +1 more source
, 2019 Quality management proposal for the W-STEM Capacity-Building project (Ref. 598923-EPP-1-2018-1-ES-EPPKA2-CBHE-JP) presented in the kick-off meeting in Salamanca (Spain) on 25-27 March 2019.
openaire +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Water quality issues in the Illinois River watershed: A proposal for new voluntary incentives [PDF]
, 2006 Concerns about water quality degradation exist in Northwest Arkansas. The purpose of this study was to analyze the potential usefulness of U.S. conservation programs in addressing water quality concerns on farms in the Illinois River watershed as well as
Hodges, Tory B., Popp, Jennie S.
core +2 more sources
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Presenteeism and social interaction in the “new normal” in Japan: a longitudinal questionnaire study
Environmental Health and Preventive MedicineBackground: Although social interaction and social support during the “new normal” due to coronavirus disease 2019 (COVID-19) may be related to presenteeism, the effect between these factors has not been clear for Japanese workers.
Megumi Yoshigai +5 more
doaj +1 more source