Results 101 to 110 of about 168,717,297 (239)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Quality Assurance Policies and Indicators for Long-Term Care in the European Union, Country Report: Slovenia. ENEPRI Research Report No. 103, February 2012 [PDF]

, 2012
In Slovenia, the government’s Strategy of Care for the Elderly up to 2010 attempted to introduce a new model to support families with elderly members, new programmes for elderly care with individual solutions and supportive social networks to foster the ...
Macjen, Boris, Rupel, Valentina Prevolnik, Ogorevc, Marko   +2 more
core  

Quality of Long-Term Care for Older People in Residential Settings – Perceptions of Quality of Life and Care Satisfaction From Residents and Their Family Members

Nursing Praxis in Aotearoa New Zealand, 2015
Older people living in long-term care homes are exposed to diverse circumstances, which may be associated with loss of independence, social networks and life satisfaction.
Polly Yeung, Vivien Rodgers
doaj  

Patient satisfaction and willingness as indicators for patient perspectives toward trainee involvement: a systematic review

BMC Medical Education
Purpose Medical trainees learn from treating patients. Patients’ refusal of trainees as caregivers influences the types of patients who trainees see and thereby their learning.
Sarah de Bever, Mana Nasori, Helianne Wisse, Mechteld Visser, Nynke van Dijk   +4 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Mapping heat-related morbidity burden attributable to human-induced climate change across 460 communities of Victoria, Australia

Environmental Health
Background With the continued rise in global temperature, the health risks associated with heat have become increasingly prominent. This study aims to assess and map the risk and cost of hospital admissions and emergency department (ED) visits ...
Yunfei Xing, Rongbin Xu, Zhihu Xu, Zhaoyuan Li, Zhengyu Yang, Yiwen Zhang, Wenzhong Huang, Pei Yu, Shanshan Li, Yuming Guo   +9 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Quality Assurance Policies and Indicators for Long-Term Care in the European Union, Country Report: Austria. ENEPRI Research Report No. 105, February 2012 [PDF]

, 2012
In Austria, the responsibilities for long-term care mainly lie with the provinces, although federal and organisational-level initiative has grown. Quality assurance policies focus overwhelmingly on the health system and are only slowly appearing in the ...
Kalmar, Marcel, Kraus, Markus, Czypionka, Thomas   +2 more
core  

UK Biobank data demonstrate long-term exposure to floods is a risk factor for incident dementia

Communications Medicine
Background Flooding has emerged as the most prevalent natural disaster, impacting billions of individuals worldwide. However, the long-term effects of flooding exposure on dementia remain unclear.
Yao Wu, Rongbin Xu, Danijela Gasevic, Zhengyu Yang, Pei Yu, Bo Wen, Yanming Liu, Guowei Zhou, Yan Zhang, Jiangning Song, Hong Liu, Shanshan Li, Yuming Guo   +12 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source