Results 91 to 100 of about 2,678,403 (260)

Searching for non-English literature may be unnecessary for German HTA Reports [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved]

F1000Research
Background Health technology assessment (HTA) reports are based on comprehensive information retrieval. Current standards discourage the use of search restrictions, such as publication date and language.
Stefan Sauerland, Wiebke Sieben, Lisa Schell, Sandra Molnar, Sibylle Sturtz, Elke Hausner   +5 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Measuring relatives' perspectives on the quality of palliative care: the Consumer Quality Index Palliative Care

, 2013
Context: A Consumer Quality Index (CQ-index) is a questionnaire assessing the actual care experiences and how important the recipient finds certain care aspects, as well as the priorities for improving quality.
Francke, A.L., Claessen, Susanne JJ, Veer, A.J.E. de, Deliens, L., de Veer, Anke JE, Claessen, S.J.J., Sixma, Herman J, Francke, Anneke L, Sixma, H.J., de Veer, A.J.E., Deliens, Luc   +10 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Oral care : identifying quality improvement areas

, 2019
Purpose: To describe and compare nurses' and healthcare assistants' oral care qualityperceptions, including perceived reality and subjective importance, to identify improvementareas in intensive care and short-term care, and to explore potential nursing ...
Wilde-Larsson, Bodil,, Andersson, Maria,, Persenius Wentzel, Mona,   +2 more
core   +1 more source

Criteria and practical guidance for determination of brain death in adults (2nd edition)

Chinese Medical Journal, 2019
Peng Lyu, Brain Injury Evaluation Quality Control Center of National Health Commission; Neurocritical Care Committe of the Chinese Society of Neurology (NCC/CSN); Neurocritical Care Committe of China Neurologist Association (NCC/CNA)   +1 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Methods used to develop quality of care standards and indicators for mental health across the WHO European region: a rapid systematic review

BMJ Open Quality
Objective This rapid review aims to understand whether a standardised approach to developing quality standards and indicators for mental health has been used across the WHO European Region and beyond to inform methods to develop quality standards for ...
Joao Breda, Jennifer Hall, Ledia Lazëri, Raffaella Sibilio   +3 more
doaj   +1 more source