Results 91 to 100 of about 168,717,297 (239)
Quality of Care and Job Satisfaction in the European Home Care Setting: Research Protocol
, 2016 Introduction: Since the European population is ageing, a growing number of elderly will need home care. Consequently, high quality home care for the elderly remains an important challenge.
Van Eenoo, Liza +7 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Exploration of support workers and volunteers initiation of advance care planning and quality of life conversations in palliative care. [PDF]
, 2018 Treetops Hospice Care, in partnership with University of Derby are commencing a research project exploring the outcomes of developing support workers and volunteers, in initiating conversations around quality of life.
Hembrow, Alison, Watson, Sharan
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
National Quality Framework snapshot Q2 2015
, 2015 This 10th report in the National Quality Framework series rates children’s education and care services across Australia. Findings include: 14 910 children’s education and care services operating under the NQF across Australia 9347 or 63 per cent of ...
Australian Children’s Education and Care Quality Authority
core
Children's health and safety: an analysis of Quality Area 2 of the National Quality Standard [PDF]
, 2016 ACECQA has published the second in its series of occasional papers, analysing one of the most challenging quality areas - Children’s Health and Safety.
Australian Children’s Education and Care Quality Authority
core
International Journal for Equity in HealthBackground Over the past decade, Greece has received a high number of applications for international protection, creating an urgent need for comprehensive mental health and psychosocial support (MHPSS) systems for asylum seekers and refugees. Despite its
Lars Dumke +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source