Results 111 to 120 of about 2,678,403 (260)

The year of transparency: measuring quality of cardiac care

, 2015
The assessment of quality of care is becoming increasingly important in healthcare, both globally and in the Netherlands. The Dutch Minister of Health declared 2015 to be the year of transparency, thereby aiming to improve quality of care by transparent ...
Bruijne, M.C. de, de Bruijne, M.C., B.A.J.M. de Mol, E. Wierda, Mol, B.A.J.M. de, D.C. D.C.Eindhoven, M.C. de Bruijne, D.C. Eindhoven, de Mol, B. A. J. M., Borleffs, C.J.W., de Bruijne, M. C., Umans, V. A. W. M., C.J.W. Borleffs, Schalij, M. J., De Mol, B.A.J.M., B.A.J.M. Mol, M.J. Schalij, Borleffs, C. J. W., Schalij, M.J., Wierda, E., Eindhoven, D.C., Umans, V.A.W.M., Eindhoven, D. C., G. Amoroso, V.A.W.M. Umans, Amoroso, G., M.C. Bruijne   +26 more
core   +1 more source

Quality of Long-Term Care for Older People in Residential Settings – Perceptions of Quality of Life and Care Satisfaction From Residents and Their Family Members

Nursing Praxis in Aotearoa New Zealand, 2015
Older people living in long-term care homes are exposed to diverse circumstances, which may be associated with loss of independence, social networks and life satisfaction.
Polly Yeung, Vivien Rodgers
doaj  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Improving primary health care for children and adolescents in Europe

Global Pediatrics
Primary health care for children in Europe is often not optimal. Primary care providers might not have been trained adequately in dealing with common conditions affecting children and adolescents, and outdated practices often persist.
Martin W. Weber, Sophie Jullien, Cassie Redlich, Jennifer Hall, Susanne Carai   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

129 Exploration of volunteers and support workers initiation of quality of life conversations in hospice palliative day care

, 2019
Treetops Hospice, in partnership with University of Derby have commenced a research project exploring the outcomes of developing volunteers, in initiating conversations around quality of life.
Alison Hembrow, Sharan Watson, Hembrow, Alison, Watson, Sharan   +3 more
core   +1 more source

Patient satisfaction and willingness as indicators for patient perspectives toward trainee involvement: a systematic review

BMC Medical Education
Purpose Medical trainees learn from treating patients. Patients’ refusal of trainees as caregivers influences the types of patients who trainees see and thereby their learning.
Sarah de Bever, Mana Nasori, Helianne Wisse, Mechteld Visser, Nynke van Dijk   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Mapping heat-related morbidity burden attributable to human-induced climate change across 460 communities of Victoria, Australia

Environmental Health
Background With the continued rise in global temperature, the health risks associated with heat have become increasingly prominent. This study aims to assess and map the risk and cost of hospital admissions and emergency department (ED) visits ...
Yunfei Xing, Rongbin Xu, Zhihu Xu, Zhaoyuan Li, Zhengyu Yang, Yiwen Zhang, Wenzhong Huang, Pei Yu, Shanshan Li, Yuming Guo   +9 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source