Results 51 to 60 of about 168,717,297 (239)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The searchbuildR shiny app: A new implementation of the objective approach for search strategy development in systematic reviews

Cochrane Evidence Synthesis and Methods
Introduction One of the main tasks in information retrieval is the development of Boolean search strategies for systematic searches in bibliographic databases. This includes the identification of free‐text terms and controlled vocabulary.
Claudia Kapp, Naomi Fujita‐Rohwerder, Jona Lilienthal, Wiebke Sieben, Siw Waffenschmidt, Elke Hausner   +5 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

A prospective cluster randomized trial of an interventions bundle to reduce inappropriate antibiotic use for upper respiratory tract infections in the outpatient setting

BMC Infectious Diseases
Background Antibiotic overuse and increasing antimicrobial resistance are global public health threats. We determined the impact of a multicomponent intervention in reducing inappropriate antibiotic use for upper respiratory tract infections (URTIs) in ...
Adeel A. Butt, Sherin Shams, Atika Jabeen, Asma Ali Al-Nuaimi, Jeyaram Illiayaraja Krishnan, Aimon B. Malik, Samah Saleem, Maryam Hassan Abdulaziz, Naheel Ismail Seyam, Kamran Aziz, Dalia Kandil, Anil G. Thomas, Hanaa Nafady-Hego, Muzna I. Lone, Jameela Al Ajmi, Zain A. Bhutta, Noora AlSulaiti, Wael E. Said Hussein, Sandy Semaan, Samya Ahmad Al-Abdulla, Mohamed Ghaith Al-Kuwari, Abdul-Badi Abou-Samra   +21 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reliability of the interRAI suite of assessment instruments: a 12-country study of an integrated health information system [PDF]

, 2008
Background A multi-domain suite of instruments has been developed by the interRAI research collaborative to support assessment and care planning in mental health, aged care and disability services.
Bjorkgren, M., Gray Len, Gunnar Ljunggren, Morris John N, Finne-Soveri, H., Ljunggren Gunnar, Gray, L., Gilgen Reudi, Björkgren Magnus, Hirdes, J.P., Len Gray, Dinnus HM Frijters, Morris, J.N., John P Hirdes, Reudi Gilgen, Frijters, D.H.M., Ljunggren, G., Finne Soveri Harriet, Magnus Björkgren, John N Morris, Gilgen, R., Hirdes John P, Frijters Dinnus HM, Harriet Finne Soveri   +23 more
core   +3 more sources

The DMP atlas for North Rhine-Westphalia, Germany: results of the disease management programmes on district level

Research in Health Services & Regions
Disease Management Programmes (DMP) in Germany were initiated to enhance the quality of ambulatory health care for specific chronic diseases. They aim to prevent the progression of the disease and comorbidity as well as to improve quality of life.
Sabine Groos, Jens Kretschmann, Arne Weber, Michaela Assheuer, Bernd Hagen   +4 more
doaj   +1 more source