Results 61 to 70 of about 168,717,297 (239)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The quality of caring relationships. [PDF]

, 2009
Tineke A Abma, Barth Oeseburg, Guy AM Widdershoven, Marian VerkerkMedical Humanities/EMGO Institute, VU Medical Center, Amsterdam, The NetherlandsAbstract: In health care, relationships between patients or disabled persons and professionals are at least ...
Verkerk, M., Tineke A Abma, Marian Verkerk, Tineke Abma, Abma, T.A., Barth Oeseburg, Guy AM Widdershoven, Oeseburg, B., Widdershoven, G.A.M.   +8 more
core   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Long-Term Care Quality Assurance Policies in the European Union. ENEPRI Research Report No. 111, March 2012 [PDF]

, 2012
This report analyses the quality assurance policies for long-term care (LTC) in the following countries: Austria, Estonia, Finland, France, Germany, Hungary, Italy, Latvia, Poland, Slovakia, Slovenia, Spain, Sweden, the Netherlands, and the United ...
Pelone, Ferruccio, Avolio, Maria, Casanova, Georgia, Dandi, Roberto, De Belvis, Antonio Giulio, Volpe, Massimo   +5 more
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Quality Assurance Policies and Indicators for Long-Term Care in the European Union. ENEPRI Policy Brief No. 11, February 2012 [PDF]

, 2012
This Policy Brief summarises findings from Work Package (WP) 5 of the ANCIEN project and its three objectives: first, collecting comprehensive information on national quality assurance policies and indicators in LTC systems in 15 EU member states; second,
Dandi, Roberto
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Design of a retrospective patient record study on the occurrence of adverse events among patients in Dutch hospitals [PDF]

, 2009
Background: Various international studies have shown that a substantial number of patients suffer from injuries or even die as a result of care delivered in hospitals.
van der Wal Gerrit, Bruijne, M.C. de, Maurits W van Tulder, Asscheman Henk, van Tulder Maurits W, Waaijman, Roelof, Waaijman, R., de Bruijne, M.C., Asscheman, Henk, van der Wal, Gerrit, Zegers Marieke, Hoonhout, L.H.F., Peter Spreeuwenberg, Spreeuwenberg, Peter, Tulder, M.W. van, van der Wal, G., Wal, Gerrit van der, de Bruijne, Martine C., Marieke Zegers, Hoonhout Lilian HF, Lilian HF Hoonhout, Cordula Wagner, Wal, G. van der, Wagner, C., van Tulder, M.W., Wagner, Cordula, Zegers, H.W.M., Gerrit van der Wal, Martine C de Bruijne, Henk Asscheman, Groenewegen, Peter P., Spreeuwenberg Peter, de Bruijne Martine C, Zegers, M., Roelof Waaijman, Wagner Cordula, Spreeuwenberg, P., van Tulder, Maurits W., Hoonhout, Lilian H. F., Waaijman Roelof, Zegers, Marieke, Asscheman, H., Bruijne, Martine C. de, van Tulder, M.W.; id_orcid   +43 more
core   +4 more sources

Causal effects of wildfire PM2.5 on hospital costs and length of stay in Brazil

Nature Communications
To quantify the hospital burden of short-term wildfire-specific fine particulate matter (PM2.5), we linked 184.5 million patient-level hospitalizations across 449 Brazilian regions from 2000–2019 with daily wildfire-specific and non-wildfire PM2.5 ...
Ke Ju, Rongbin Xu, Wenzhong Huang, Yiwen Zhang, Tingting Ye, Wenhua Yu, Zhengyu Yang, Gongbo Chen, Yanming Liu, Pei Yu, Shuang Zhou, Yao Wu, Bo Wen, Zhihu Xu, Paulo H. N. Saldiva, Micheline S. Z. S. Coelho, Jiangning Song, Shanshan Li, Yuming Guo   +18 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source