Results 121 to 130 of about 8,406,316 (344)

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

open access: yesFEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke   +2 more
wiley   +1 more source

The value and quality of life

open access: yesEuropean Review, 1999
A medical view on ‘the value of life’ can be inferred from medical accounts of the quality of life: a life has value if it embodies certain qualities. Scales have been developed to quantify quality of life. While the term ‘quality of life’ is used frequently in everyday discourse, perceptions of what it might actually mean differ greatly and are often ...
openaire   +3 more sources

A working model for cytoplasmic assembly of H/ACA snoRNPs

open access: yesFEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

When Choice Itself Hurts the Quality of Life [PDF]

open access: yes, 2016
“When Choice Itself Hurts the Quality of Life” (how the results of choice may be seen as the fault of the chooser), Human Life Review, vol. XLII, No. 4, Fall 2016.
Stith, Richard
core   +1 more source

Validation of the cancer-specific utility measure EORTC QLU-C10D using evidence from four lung cancer trials covering six country value sets

open access: yesScientific Reports
The Quality of Life (QoL) Utility measure, QLU-C10D, is derived of the European Organisation for Research and Treatment of Cancer (EORTC) QoL Questionnaire, QLQ-C30.
Simone Seyringer   +9 more
doaj   +1 more source

The Impact of Endometriosis on Women’s Quality of Life and Sexual Life

open access: yesArchives of Health Science and Research
Objective: This study was carried out to determine the effect of endometriosis on women’s sexual life and quality of life. Methods: A comparative descriptive study was conducted with 194 women (97 women diagnosed with endometriosis and 97 healthy ...
Melike DİŞSİZ   +5 more
doaj   +1 more source

Glaucoma Quality of Life [PDF]

open access: yesJournal of Ophthalmology, 2017
FEA, Antonio Maria   +3 more
openaire   +6 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

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