FoxO1 signaling in B cell malignancies and its therapeutic targeting
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac+3 more
wiley +1 more source
Pengaruh Quality of Work Life Terhadap Work Engagement Dan Organizational Citizenship Behaviour Pada Perusahaan Elektronik Di Surabaya [PDF]
Tujuan dari penelitian untuk mengetahui pengaruh Quality of Work Life terhadap Work Engagement dan Oraganizational Citizenship Behaviour pada Perusahaan Elektronik di Surabaya.
Kurniawati, C. E. (Chaterine)
core
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Third European Quality of Life Survey – Quality of Life in Europe: Families in the Economic Crisis [PDF]
[Excerpt] The European Quality of Life Survey (EQLS) provides a reliable picture of the living conditions and the social situation of Europeans before and during the economic crisis. But how has the crisis affected families with children?
Ahrendt, Daphne+2 more
core +1 more source
Subjective quality of life in war-affected populations [PDF]
PMCID: PMC3716711This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided
Ajdukovic, D+11 more
core +3 more sources
OVERVIEW OF ORAL HEALTH RELATED QUALITY OF LIFE INDICATORS
The instruments that evaluate the health-related quality of life are extremely useful in the medical practice and research since they allow the full approach of patient’s general status. They come in the shape of questionnaires whose usage may be carried
Alice Murariu+9 more
doaj
An evaluation of life satisfaction and health – Quality of life of senior citizens
Introduction Modern medicine is still searching for the antecedents which will lead to [i]successful aging[/i]. The article discusses the self-perception of life satisfaction and health of senior citizens.
Artur Ziółkowski+2 more
doaj +1 more source
Topophilia and the Quality of Life [PDF]
With this research I tested the hypothesis that individual preferences for specific ecosystem components and restorative environments are significantly associated with quality of life (QOL). A total of 379 human subjects responded to a structured 18-item questionnaire on topophilia and to the 26-item World Health Organization's Quality of Life (WHOQOL ...
openaire +6 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
A stepwise emergence of evolution in the RNA world
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source