Results 101 to 110 of about 168,723,046 (286)

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Health-related quality of life in epilepsy: findings obtained wiht a new italian instrument.

, 2008
The aim of the present study was to evaluate the Epi-QoL, a new Italian-specific measure of health-related quality of life (HRQOL) for adults with epilepsy; the clinical variables that affected the HRQOL score were also assessed.
K. Turner, E. Beghi, M. Ferraroni, LICE Quality Of Life Group, SPECCHIO, LUIGI MARIA, A. Piazzini   +5 more
core   +1 more source

The adherence–quality of life paradox in tuberculosis care after COVID-19: a cross-sectional study in Indonesia

Discover Public Health
Introduction Tuberculosis (TB) remains one of Indonesia’s most pressing public health challenges, particularly in the post-COVID-19 era. Medication adherence is widely considered critical to TB treatment success and is often linked to improved quality of
Devi Ristian Octavia, Andi Hermansyah, Yunita Nita, Yuni Priyandani, Liza Pristianty, Long Chiau Ming, Nada A. Alsaleh, Alaa A. Alsharif, Sherly Meilianti   +8 more
doaj   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Exploring the Lived experiences and quality of life of mental health care users in chronic psychiatric facilities in KwaZulu- Natal.

South African Journal of Occupational Therapy
Introduction: The quality of life for mental health care users in public sector psychiatric facilities remains a significantly under-researched area in South Africa.
Fundiswa Mvubu, Phezisa Matandabuzo, Thandolwethu Tshabalala, Izwakele Hlengwa , Kerriska Naidu, Thavanesi Gurayah   +5 more
doaj   +1 more source

Resilience as a mediator of quality of life in cancer patients in healthcare services

Scientific Reports
Quality of life is a critical outcome in oncology, influencing treatment adherence and patient satisfaction. Haematology patients face psychological challenges, including emotional distress, depression and PTSD, which can affect their quality of life.
Caldiroli C. L., Sarandacchi S., Tomasuolo M., Diso D., Castiglioni M., Procaccia R.   +5 more
openaire   +3 more sources

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Professional Quality of Life Among Non-Specialist Healthcare Workers Trained in Child and Adolescent Mental Health in Kenya: A Mixed-Methods Study

Journal of Multidisciplinary Healthcare
Beatrice Mkubwa,1,2 Vibian Angwenyi,1 Rachel Odhiambo,1 Charles R Newton,3,4 Marit Sijbrandij,2 Amina Abubakar1,3,41Institute for Human Development, Aga Khan University, Nairobi, Kenya; 2Department of Clinical, Neuro- and Developmental Psychology, WHO ...
Mkubwa B, Angwenyi V, Odhiambo R, Newton CR, Sijbrandij M, Abubakar A   +5 more
doaj  

Enhancing Therapy Adherence: Impact on Clinical Outcomes, Healthcare Costs, and Patient Quality of Life

Medicina
Adherence to therapy, defined as the extent to which a patient follows prescribed therapeutic recommendations, is a pivotal factor in the effective management of chronic diseases such as diabetes, hypertension, and cardiovascular conditions.
Urszula Religioni, Rocío Barrios-Rodríguez, Pilar Requena, Mariola Borowska, Janusz Ostrowski   +4 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source