Results 91 to 100 of about 722,621 (262)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Quality of Life of Healthcare College Students in Riyadh, Saudi Arabia

Cureus
The aim of this study was to assess the quality of life (QOL) and its influencing factors among healthcare college students in Riyadh, Saudi Arabia.A cross-sectional study was conducted among healthcare students at King Saud University. A modified version of the Arabic World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaire ...
Talakey, Arwa, Tounsi, Abrar, Alhusan, Reyouf, Alabdely, Maha, Alhamedi, Reem   +4 more
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Grupo de reflexão com profissionais de uma Unidade de Terapia Intensiva Coronariana: um relato de experiência

Revista Brasileira de Saúde Ocupacional
Resumo Objetivo: descrever uma intervenção grupal realizada com os profissionais de uma equipe de saúde de uma Unidade de Terapia Intensiva Coronariana. Métodos: trata-se de um relato de experiência, em forma de narrativa, realizado por uma psicóloga-
Suellen Rosana Costa Amaral, Andréia Elisa Garcia de Oliveira   +1 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Quality of life among people with disabilities and its related factors in Iran: a cross-sectional study

BMC Public Health
Introduction Disability is a multifaceted global public health issue that adversely affects individuals’ quality of life (QoL), especially in low- and middle-income countries such as Iran.
Fatemeh Darabi, Zahra Najafi, Kamran Arvan, Nadia Mohammadi, Fatemeh Khosravi Shadmani, Shahin Soltani   +5 more
doaj   +1 more source

Effects of Spinal Decompression and Segmental Spinal Instrumentation on Lower Limb Functionality in Patients with Spinal Osteoarthritis

Life
Spinal osteoarthritis, a degenerative condition of the spine, significantly impairs quality of life, causing pain, stiffness, and limited mobility. Treatment primarily aims to improve functionality and quality of life. This study investigated the effects
Milan Mirković, Filip Kukić, Dragan Mirkov, Dejan Marinković, Lazar Mičeta, Sanja Mirković, Biljana Božić Nedeljković, Zoran Baščarević   +7 more
doaj   +1 more source

Resilience as a mediator of quality of life in cancer patients in healthcare services

Scientific Reports
Quality of life is a critical outcome in oncology, influencing treatment adherence and patient satisfaction. Haematology patients face psychological challenges, including emotional distress, depression and PTSD, which can affect their quality of life.
Caldiroli C. L., Sarandacchi S., Tomasuolo M., Diso D., Castiglioni M., Procaccia R.   +5 more
openaire   +3 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source