Results 71 to 80 of about 168,723,046 (286)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Lower Healthcare Access and Its Association With Individual Factors and Health-Related Quality of Life in Adults With Rare Diseases in Switzerland

International Journal of Public Health
ObjectivesThis study aims to determine clusters of access to healthcare among adults with rare diseases in Switzerland, identify associated individual characteristics of access, and impact on health-related quality of life (HRQoL).MethodsSwiss adults (N =
Susanne Wehrli, Susanne Wehrli, Susanne Wehrli, Andrew A. Dwyer, Andrew A. Dwyer, Matthias R. Baumgartner, Matthias R. Baumgartner, Carmen Lehmann, Markus A. Landolt, Markus A. Landolt, Markus A. Landolt   +10 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Gammarid Amphipods as a Potential Source of Omega-3 LC PUFA-Rich Biomass for Functional Ingredients: Nutritional Potential, Controlled Production, and Safety Constraints

Applied Sciences
New health-promoting food ingredients should combine nutritional functionality, traceable production and sustainable sourcing. Freshwater and brackish gammarid amphipods are usually considered ecological indicators, fish prey or invasive crustaceans, but
Wojciech Kolanowski, Roberta Foligni
doaj   +1 more source

Healthcare Utilization and the Quality of Life of Children and Adolescents with Sickle Cell Disease

Pediatric Blood & Cancer, 2021
Introduction: Youth diagnosed with sickle cell disease (SCD) often utilize the healthcare setting to manage disease-related symptoms, yet the connection between healthcare use and their overall wellbeing has been understudied. This study investigates whether healthcare utilization predicts the health-related quality of life (HRQOL) in youth with SCD ...
openaire   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Omega-3-Fortified Foods as Designed Delivery Systems: Source Quality, Matrix Performance, Retained Dose, and Evidence-Based Claims

Applied Sciences
Omega-3-fortified foods sit at the interface of lipid science, food technology, and prevention-oriented nutrition. The aim of this narrative review is to define practical criteria for evaluating whether fortified foods can deliver physiologically ...
Wojciech Kolanowski, Roberta Foligni
doaj   +1 more source

Musculo-skeletal Disorders and Quality of Life among Primary Healthcare Dentists in Menoufia Governorate, Egypt [PDF]

Egyptian Journal of Health Care
Background: One of the main occupational diseases among dentists is musculoskeletal disorders (MSDs). Their quality of life and productivity at work might become negatively affected by these issues.
Faten Ezzelarab Younis, Asmaa Abubakr Mohammed, Aziza Saad El-Badry   +2 more
doaj   +1 more source

FATIGUE AND QUALITY OF LIFE IN EMERGENCY HEALTHCARE PROFESSIONALS

Texto & Contexto - Enfermagem
ABSTRACT Objective: to identify the prevalence of fatigue and the relationship between professional, health and quality of life variables of professionals working in emergency care services. Method: a cross-sectional study, with 108 healthcare professionals, carried out in midwest Brazil, in 2021, using the Chalder Fatigue Scale and the World Health
Mariana Alvina dos Santos, Bruna Moretti Luchesi, Victoria Laura Facin, Edirlei Machado dos Santos, Silmara Elaine Malaguti Toffano, Flavia Helena Pereira, Vivian dos Anjos Azambuja, Vinicius Batista dos Santos   +7 more
openaire   +2 more sources