Results 71 to 80 of about 67,124 (258)

The impact of hospital saturation on non-COVID-19 hospital mortality during the pandemic in France: a national population-based cohort study

BMC Public Health
Background A previous study reported significant excess mortality among non-COVID-19 patients due to disrupted surgical care caused by resource prioritization for COVID-19 cases in France.
Laurent Boyer, Vanessa Pauly, Yann Brousse, Veronica Orleans, Bach Tran, Dong Keon Yon, Pascal Auquier, Guillaume Fond, Antoine Duclos   +8 more
doaj   +1 more source

Stress Is Associated with Quality of Life Reduction among Health Professionals in Vietnam: A Multisite Survey

Mental Illness, 2023
Stress in healthcare workers is increasingly common in recent times. Stress can have negative effects on the mental health and quality of life of healthcare workers.
Le Thi Kieu Hanh, Ngo Van Toan, Vu Minh Hai   +2 more
doaj   +1 more source

The Role of Transformational Leadership in Enhancing Patient Quality of Life Outcomes

, 2022
Introduction: The study explored the impact of transformational leadership on patient quality of life outcomes in healthcare settings. Transformational leadership, characterized by inspiring and motivating staff, was hypothesized to influence patient ...
Sahoo , Aswini Kumar, Sharma , Ashok Kr, Gupta, Kashish, RenukaJyothi , S.   +3 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Quality of Life and the Role of Integrated Care Models in Healthcare

Introduction: Quality of life use has gained attention from healthcare professionals due to its broad intersections of factors from personal relationships to social support to psychological well-being and physical health.
Malla, Asish, Singh , Jaskirat, Mohite, Rajsinh V., Parashar , Mukesh, Patel, Geetika M., Sharma , Divya   +5 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Evaluation of health care system quality in the context of medical reform [PDF]

Journal of Social Sciences, 2019
The article deals with the problem of medical services quality assessment as a factor that increases the average life expectancy and population life quality.
GOROBIEVSCHI, Svetlana, CAUȘAN, Corina
doaj   +1 more source

Knowledge translation resources to support the use of quality of life assessment tools for the care of older adults living at home and their family caregivers

, 2022
PURPOSE: To support the use of quality of life (QOL) assessment tools for older adults, we developed knowledge translation (KT) resources tailored for four audiences: (1) older adults and their family caregivers (micro), (2) healthcare providers (micro),
Sawatzky, Richard,, Cuthbertson, Lena, Duquette, Dominique, Terblanche, Landa, Stajduhar, Kelli I., Cohen, S. Robin, Schick-Makaroff, Kara, Beemer, Autumn, Karimi-Dehkordi, Mehri, Öhlén, Joakim,, Wolff, Angela C., Sawatzky, Richard, Suryaprakash, Nitya, Öhlén, Joakim   +13 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source