Results 61 to 70 of about 67,124 (258)

Quality of life and healthcare utilisation in cystic fibrosis: a multicentre study [PDF]

European Respiratory Journal, 2012
The aim of our study was to discover the health status and healthcare utilisation associated with pulmonary exacerbations in cystic fibrosis (CF) and chronicPseudomonas aeruginosainfection.Patients with CF from five UK CF centres attended two visits, 8–12 weeks apart.
Bradley, Judy M, Blume, Steven W, Balp, Maria-Magdalena, Honeybourne, David, Elborn, J Stuart   +4 more
openaire   +3 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Workplace violence against healthcare workers in rural health facilities of Bangladesh and their quality of life: A cross-sectional study

Bangabandhu Sheikh Mujib Medical University Journal
Background: The prevalence of verbal and physical violence against healthcare workers (HCWs) is reportedly high in Bangladesh. We aimed to determine the prevalence and risk factors associated with violence against HCWs in Bangladesh. Methods: This cross-
Md Atiqul Haque, Zubair Ahmed Ratan, Abid Hasan Khan, Sabrina Mousum, Muhammad Ibrahim Ibne Towhid, Md Enayet Ullah, Md Maruf Haque Khan, Mohammad Tanvir Islam   +7 more
doaj   +3 more sources

Associations between multimorbidity and additional burden for working-age adults with specific forms of musculoskeletal conditions: a cross-sectional study

BMC Musculoskeletal Disorders, 2017
Background Multiple health conditions are increasingly a problem for adults with musculoskeletal conditions. However, multimorbidity research has focused primarily on the elderly and those with a limited subset of musculoskeletal disorders.
Dianne B. Lowe, Michael J. Taylor, Sophie J. Hill   +2 more
doaj   +1 more source

Investigating organizational quality improvement systems, patient empowerment, organizational culture, professional involvement and the quality of care in European hospitals: the 'Deepening our Understanding of Quality Improvement in Europe (DUQuE)' project. [PDF]

, 2010
BACKGROUND: Hospitals in European countries apply a wide range of quality improvement strategies. Knowledge of the effectiveness of these strategies, implemented as part of an overall hospital quality improvement system, is limited.
Andrew Thompson, Klazinga, Niek, Arah Onyebuchi A, Suñol, Rosa, Arah, O.A., Groene Oliver, Klazinga Niek, Charles Bruneau, Thompson, Andrew, Cordula Wagner, Klazinga, N., Groene, O., Wagner, C., Wagner, Cordula, Suñol Rosa, Arah, Onyebuchi A.., Onyebuchi A Arah, Arah, O. A., Thompson Andrew, Rosa Suñol, Deepening our Understanding of Quality Improvement in Europe Res, Sunol, R., Arah, Onyebuchi A, ?, ?, Niek Klazinga, null null, Oliver Groene, Bruneau, Charles, Wagner Cordula, Bruneau Charles, Arah, Onyebuchi A., Groene, Oliver, Suñol Sala, Rosa, Bruneau, C., Thompson, A.   +34 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Effect of Progressive Healthcare Management on the Improvement of Patient Quality of Life

, 2023
 Progressive healthcare management means tactics that are always changing and being used to make care for patients better and people\u27s lives better in general.
Renuka , Jyothi.R, Moharana, Lalatendu, Gupta, Kashish, Garg, Ram, Khanwelkar, C.C.   +4 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source