FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Relação entre dor crônica e atividade laboral em pacientes portadores de síndromes dolorosas
Revista DorJUSTIFICATIVA E OBJETIVOS: O presente estudo objetivou identificar a influência da dor crônica no prejuízo da atividade laboral de pacientes atendidos no Serviço de Dor Crônica do Hospital Universitário da Universidade Federal do Maranhão.
Beatriz Tavares Garcia +2 more
doaj +1 more source
Staff quality of working life and turnover intentions in municipal nursing care and social welfare: a cross-sectional study. [PDF]
BMC Nurs, 2023 Engström M, Jarnheden SH, Tham P.
europepmc +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Quality of working life of professors in times of social distancing. [PDF]
Rev Bras Med Trab, 2022 da Silva FX +3 more
europepmc +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
The relationships among overcommitment, effort-reward imbalance, safety climate, emotional labour and quality of working life for hospital nurses: a structural equation modeling. [PDF]
BMC Nurs, 2023 Liang HY +4 more
europepmc +1 more source
Emergency Medicine Palliative Care Access (EMPallA): Protocol for a multicentre randomised controlled trial comparing the effectiveness of specialty outpatient versus nurse-led telephonic palliative care of older adults with advanced illness [PDF]
, 2019 Introduction Emergency department (ED)-initiated palliative care has been shown to improve patient-centred outcomes in older adults with serious, life-limiting illnesses. However, the optimal modality for providing such interventions is unknown.
Cho, Jeanne +4 more
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Impact of the COVID-19 crisis on healthcare workers: The need to address quality of working life issues. [PDF]
Respirology, 2022 Marcellin F +7 more
europepmc +1 more source