Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The relationships among overcommitment, effort-reward imbalance, safety climate, emotional labour and quality of working life for hospital nurses: a structural equation modeling. [PDF]
BMC Nurs, 2023 Liang HY +4 more
europepmc +1 more source
Determination of Basic Factors of Influence and Indexes of Evaluation of Quality of Labour Life of Workers of Industry Определение основных факторов влияния и показателей оценивания качества трудовой жизни работников промышленности [PDF]
, 2012 In this paper the factors influencing the quality of working life of workers in industry as an example of mechanical engineering is investigated. The main components of the quality of working life is defined conditions, financial incentives, intangible ...
Stamatin Aleksandr V. +1 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Quality of working life of medical doctors and associated risk factors: a cross-sectional survey in public hospitals in China. [PDF]
BMJ Open, 2022 Tang C, Guan C, Liu C.
europepmc +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Developing a questionnaire on the quality of working life for female medical and healthcare professionals. [PDF]
Ind Health, 2021 Taketomi K +5 more
europepmc +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
QUALITY OF WORKING LIFE IN COMMODITIZED HOSPITALS AND UNIVERSITIES [PDF]
Papeles del Psicólogo, 2014 New Public Management (NPM) turns public hospital and university services into market enterprises. The aim of the paper is to analyze and describe the impact of this metamorphosis on the labor subjectivity of the staff employed in such services ...
Josep M. Blanch
doaj
The effect of COVID-19 anxiety levels of healthcare professionals on the quality of working life and related factors. [PDF]
Int J Clin Pract, 2021 Aydın A, Kulakaç N, Aydın Sayılan A.
europepmc +1 more source